Coexisting Logopenic Variant of Primary Progressive Aphasia with Amyloid Pathology and Early Parkinsonism

被引:0
|
作者
Caccamo, Martina [1 ,2 ]
Urso, Daniele [1 ,3 ]
Nanni, Alfredo Gabriele [1 ,2 ]
Gnoni, Valentina [1 ,3 ]
Giugno, Alessia [1 ]
Vilella, Davide [1 ]
Zecca, Chiara [1 ]
Dell'Abate, Maria Teresa [1 ]
Anastasia, Antonio [4 ]
De Blasi, Roberto [1 ]
Introna, Alessandro [5 ]
Logroscino, Giancarlo [1 ,2 ,3 ]
机构
[1] Univ Bari Aldo Moro, Ctr Neurodegenerat Dis & Aging Brain, Dept Clin Res Neurol, Pia Fdn Cardinale G Panico, Lecce, Italy
[2] Dept Translat Biomed & Neurosci, Neurol Unit, Bari, Italy
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neurosci, De Crespigny Pk, London, England
[4] Pia Fdn Culto & Religione Card G Panico, Dept Nucl Med, Tricase, Italy
[5] Univ Bari Aldo Moro, Dept Translat Biomed & Neurosci, Bari, Italy
关键词
Alzheimer's disease; amyloid; amyloid PET; logopenic variant; parkinsonism; primary progressive aphasia; ALZHEIMERS-DISEASE; DIAGNOSIS; CRITERIA;
D O I
10.3233/ADR-230168
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The presence of parkinsonism features in primary progressive aphasia (PPA) is a subject of ongoing research. These features are usually more pronounced in the advanced stages of the disease, particularly in the non-fluent/agrammatic subtype, and are exceptionally rare in the logopenic variant (lvPPA). Here we report a case of a 63-year-old man presenting as language impairment, predominantly naming and word-finding difficulties, emerged alongside a left-sided internal tremor. Neurological examination revealed bilateral, left-side predominant rigidity, bradykinesia, and resting tremor. Notably, anosmia and constipation were present. Language assessments showed preserved single-word comprehension, object knowledge, and a minimal apraxia of speech, as well as sentence repetition issues. Neuroimaging and biomarker analysis supported a diagnosis of primary progressive logopenic aphasia with amyloid pathology co-existing with prominent and early parkinsonism. This case underlines the intricate relationship between language disorders, parkinsonism, and amyloid pathology in lvPPA.
引用
收藏
页码:1023 / 1030
页数:8
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