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Coexisting Logopenic Variant of Primary Progressive Aphasia with Amyloid Pathology and Early Parkinsonism
被引:0
|作者:
Caccamo, Martina
[1
,2
]
Urso, Daniele
[1
,3
]
Nanni, Alfredo Gabriele
[1
,2
]
Gnoni, Valentina
[1
,3
]
Giugno, Alessia
[1
]
Vilella, Davide
[1
]
Zecca, Chiara
[1
]
Dell'Abate, Maria Teresa
[1
]
Anastasia, Antonio
[4
]
De Blasi, Roberto
[1
]
Introna, Alessandro
[5
]
Logroscino, Giancarlo
[1
,2
,3
]
机构:
[1] Univ Bari Aldo Moro, Ctr Neurodegenerat Dis & Aging Brain, Dept Clin Res Neurol, Pia Fdn Cardinale G Panico, Lecce, Italy
[2] Dept Translat Biomed & Neurosci, Neurol Unit, Bari, Italy
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neurosci, De Crespigny Pk, London, England
[4] Pia Fdn Culto & Religione Card G Panico, Dept Nucl Med, Tricase, Italy
[5] Univ Bari Aldo Moro, Dept Translat Biomed & Neurosci, Bari, Italy
关键词:
Alzheimer's disease;
amyloid;
amyloid PET;
logopenic variant;
parkinsonism;
primary progressive aphasia;
ALZHEIMERS-DISEASE;
DIAGNOSIS;
CRITERIA;
D O I:
10.3233/ADR-230168
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
The presence of parkinsonism features in primary progressive aphasia (PPA) is a subject of ongoing research. These features are usually more pronounced in the advanced stages of the disease, particularly in the non-fluent/agrammatic subtype, and are exceptionally rare in the logopenic variant (lvPPA). Here we report a case of a 63-year-old man presenting as language impairment, predominantly naming and word-finding difficulties, emerged alongside a left-sided internal tremor. Neurological examination revealed bilateral, left-side predominant rigidity, bradykinesia, and resting tremor. Notably, anosmia and constipation were present. Language assessments showed preserved single-word comprehension, object knowledge, and a minimal apraxia of speech, as well as sentence repetition issues. Neuroimaging and biomarker analysis supported a diagnosis of primary progressive logopenic aphasia with amyloid pathology co-existing with prominent and early parkinsonism. This case underlines the intricate relationship between language disorders, parkinsonism, and amyloid pathology in lvPPA.
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页码:1023 / 1030
页数:8
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