Clinically amyopathic dermatomyositis: Clinical, laboratory, and histopathological features

被引:1
作者
Wang, Xintong [1 ]
De Moll, Ellen [2 ]
Koschitzky, Merav [2 ]
Shihab, Nahla [3 ]
Khattri, Saakshi [4 ]
Phelps, Robert [4 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Pathol, New York, NY USA
[2] Icahn Sch Med Mt Sinai, New York, NY USA
[3] Ascens St Agnes Hosp, Baltimore, MD USA
[4] Icahn Sch Med Mt Sinai, Dept Dermatol, 1468 Madison Ave, New York, NY 10029 USA
关键词
amyopathic dermatomyositis; clinically amyopathic dermatomyositis; hypomyopathic dermatomyositis; JAPANESE PATIENTS; AUTOANTIBODIES; MYOSITIS; POLYMYOSITIS;
D O I
10.1111/cup.14691
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
BackgroundDespite the advancements in the categorization of clinically amyopathic dermatomyositis (CADM), the classification and diagnosis of its subtypes are still challenging. The aim of our study was to describe the clinicopathological features of CADM and assess the differences between amyopathic dermatomyositis (ADM) and hypomyopathic dermatomyositis (HDM).MethodsThis retrospective study included 43 patients with CADM diagnosed at our institution from 2016 to 2020. Patients were subclassed into ADM (n = 30) and HDM (n = 13) groups to assess their clinicopathological differences.ResultsAll included patients had characteristic cutaneous manifestations of dermatomyositis; 67.4% had myositis-associated auto-antibodies, including ANA (32.6%), RNP (14.0%), anti-Ro52 (9.3%), anti-p155/140 (7.0%), rheumatoid factor (7.0%), anti-NXP-2 (4.7%), anti-MDA5 (2.3%), and anti-Jo-1 (2.3%) antibodies. One patient had associated interstitial lung disease, and another patient had oral squamous cell carcinoma. The histopathological findings included mucin deposition (69.8%), telangiectasia (65.1%), lymphocytic infiltrate (48.8%), vacuolar interface dermatitis (46.5%), and epidermal atrophy (14.0%). Compared to patients with HDM, ADM patients were significantly less likely to have epidermal atrophy, 3.3% versus 38.5% (p = 0.006), and more likely to have mucin deposition, 80.0% versus 46.2% (p = 0.028).ConclusionWe described the clinicopathological features of CADM and highlighted the distinctions between ADM and HDM dermatopathologic findings. This information may prove helpful in diagnosing ambiguous lesions.
引用
收藏
页码:799 / 806
页数:8
相关论文
共 50 条
[41]   Clinically amyopathic dermatomyositis: clinical features, response to medications and malignancy-associated risk factors in a specific tertiary-care-centre cohort [J].
Galimberti, F. ;
Li, Y. ;
Fernandez, A. P. .
BRITISH JOURNAL OF DERMATOLOGY, 2016, 174 (01) :158-164
[42]   Skin metastasis of breast cancer clinically undistinguished from amyopathic dermatomyositis [J].
Seishima, M ;
Shimizu, H ;
Oyama, Z .
EUROPEAN JOURNAL OF DERMATOLOGY, 2001, 11 (02) :131-133
[43]   The role of therapeutic plasma exchange in clinically amyopathic dermatomyositis withMDA-5 antibody: A case report and review of the literature [J].
Fine, Alexander ;
Karp, Julie K. ;
Peedin, Alexis R. .
JOURNAL OF CLINICAL APHERESIS, 2020, 35 (05) :483-487
[44]   Elevated carcinoembryonic antigen predicts rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis [J].
Zhu, Dingxian ;
Qiao, Jianjun ;
Tang, Shunli ;
Pan, Yunlei ;
Li, Sheng ;
Yang, Changyi ;
Fang, Hong .
RHEUMATOLOGY, 2021, 60 (08) :3896-3903
[45]   A case of clinically amyopathic dermatomyositis that was refractory to intensive immunosuppressive therapy including tofacitinib, but successfully treated with plasma exchange therapy [J].
Hiraoka, Daisuke ;
Ishizaki, Jun ;
Horie, Kenta ;
Matsumoto, Takuya ;
Suemori, Koichiro ;
Takenaka, Katsuto ;
Hasegawa, Hitoshi .
MODERN RHEUMATOLOGY CASE REPORTS, 2022, 6 (02) :194-198
[46]   Comparison of characteristics and anti-MDA5 antibody distribution and effect between clinically amyopathic dermatomyositis and classic dermatomyositis: a retrospective case-control study [J].
Ji, Qiang ;
Pan, Wenping ;
Zhang, Di ;
Hou, Yanfeng ;
Wang, Zhankui .
FRONTIERS IN IMMUNOLOGY, 2023, 14
[47]   Predictive factors of rapidly progressive-interstitial lung disease in patients with clinically amyopathic dermatomyositis [J].
Xu, Y. ;
Yang, C. S. ;
Li, Y. J. ;
Liu, X. D. ;
Wang, J. N. ;
Zhao, Q. ;
Xiao, W. G. ;
Yang, P. T. .
CLINICAL RHEUMATOLOGY, 2016, 35 (01) :113-116
[48]   Amyopathic Dermatomyositis With Plantar Keratoderma Responding to Methotrexate Therapy [J].
Morrell, Travis J. ;
Mortensen, William Soren ;
Langley, Shawna .
CUTIS, 2017, 100 (02) :E20-E24
[49]   Amyopathic dermatomyositis. [J].
Olsen N.J. ;
Park J.H. ;
King Jr. L.E. .
Current Rheumatology Reports, 2001, 3 (4) :346-351
[50]   Amyopathic dermatomyositis - An uncommon presentation of dermatomyositis [J].
Arnson, Yoav ;
Dovrish, Zamir ;
Hadari, Ruth ;
Amital, Howard .
ISRAEL MEDICAL ASSOCIATION JOURNAL, 2007, 9 (06) :492-493