Molecularly Imprinted Drug Carrier for Lamotrigine-Design, Synthesis, and Characterization of Physicochemical Parameters

被引：1

作者：

Sobiech, Monika ^{[1
]}

Khamanga, Sandile M. ^{[2
]}

Synoradzki, Karol ^{[3
]}

Bednarchuk, Tamara J. ^{[4
]}

Sikora, Katarzyna ^{[1
]}

Lulinski, Piotr ^{[1
]}

Giebultowicz, Joanna ^{[5
]}

机构：

[1] Med Univ Warsaw, Fac Pharm, Dept Organ & Phys Chem, Banacha 1, PL-02097 Warsaw, Poland

[2] Rhodes Univ, Fac Pharm, ZA-6140 Makhanda, South Africa

[3] Polish Acad Sci, Inst Mol Phys, Smoluchowskiego 17, PL-60179 Poznan, Poland

[4] Polish Acad Sci, Inst Low Temp & Struct Res, Okolna 2, PL-50323 Wroclaw, Poland

[5] Med Univ Warsaw, Fac Pharm, Dept Drug Chem Pharmaceut & Biomed Anal, Banacha 1, PL-02097 Warsaw, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

molecularly imprinted polymer; magnetic particle; drug carrier; lamotrigine; drug delivery; IN-VITRO; CONTROLLED-RELEASE; POLYMER; DELIVERY; NANOPARTICLES; EPILEPSY; DYNAMICS; SYSTEM;

D O I：

10.3390/ijms25094605

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study presents the initial attempt at introducing a magnetic molecularly imprinted polymer (MIP) designed specifically for lamotrigine with the purpose of functioning as a drug carrier. First, the composition of the magnetic polymer underwent optimization based on bulk polymer adsorption studies and theoretical analyses. The magnetic MIP was synthesized from itaconic acid and ethylene glycol dimethacrylate exhibiting a drug loading capacity of 3.4 +/- 0.9 mu g g-1. Structural characterization was performed using powder X-ray diffraction analysis, vibrating sample magnetometry, and Fourier transform infrared spectroscopy. The resulting MIP demonstrated controlled drug released characteristics without a burst effect in the phospahe buffer saline at pH 5 and 8. These findings hold promise for the potential nasal administration of lamotrigine in future applications.

引用

页数：23

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