Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering

被引：11

作者：

Armengol, Eva Sanchez ^{[1
]}

Hock, Nathalie ^{[1
,2
]}

Saribal, Sila ^{[1
]}

To, Dennis ^{[1
]}

Summonte, Simona ^{[1
,3
]}

Veider, Florina ^{[1
,4
]}

Kali, Gergely ^{[1
]}

Bernkop-Schnuerch, Andreas ^{[1
]}

Laffleur, Flavia ^{[1
]}

机构：

[1] Univ Innsbruck, Inst Pharm, Dept Pharmaceut Technol, Innrain 80-82, A-6020 Innsbruck, Austria

[2] ITM Isotope Technol Munich SE, Walther-von-Dyck Str 4, D-85748 Garching, Germany

[3] ThioMatrix Forsch & Beratungs GmbH, Trientlgasse 65, A-6020 Innsbruck, Austria

[4] Sandoz, Biochemiestr 10, A-6250 Kundl, Austria

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2024年 / 196卷

关键词：

Biomimetic; Chitosan; Keratin; Scaffolds; Tissue engineering; DRUG-DELIVERY; BACTERIAL CELLULOSE; POROUS SCAFFOLDS; CROSS-LINKING; HUMAN HAIR; IN-SITU; CHITOSAN; KERATIN; HYDROGEL; COMPOSITE;

D O I：

10.1016/j.ejps.2024.106761

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inspired by nature, tissue engineering aims to employ intricate mechanisms for advanced clinical interventions, unlocking inherent biological potential and propelling medical breakthroughs. Therefore, medical, and pharmaceutical fields are growing interest in tissue and organ replacement, repair, and regeneration by this technology. Three primary mechanisms are currently used in tissue engineering: transplantation of cells (I), injection of growth factors (II) and cellular seeding in scaffolds (III). However, to develop scaffolds presenting highest potential, reinforcement with polymeric materials is growing interest. For instance, natural and synthetic polymers can be used. Regardless, chitosan and keratin are two biopolymers presenting great biocompatibility, biodegradability and non-antigenic properties for tissue engineering purposes offering restoration and revitalization. Therefore, combination of chitosan and keratin has been studied and results exhibit highly porous scaffolds providing optimal environment for tissue cultivation. This review aims to give an historical as well as current overview of tissue engineering, presenting mechanisms used and polymers involved in the field.

引用

页数：16

共 104 条

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