Identification of clinical-biological features of newly diagnosed early relapse multiple myeloma patients eligible for autologous stem cell transplantation

被引：0

作者：

Cillo, Lorenzo ^{[1
]}

Dalla Palma, Anna Benedetta ^{[2
]}

Ricci, Stefania ^{[2
]}

Pedrazzoni, Mario ^{[1
]}

Scita, Matteo ^{[2
]}

Bernardi, Matia ^{[2
]}

Sammarelli, Gabriella ^{[2
]}

Pelagatti, Laura ^{[2
]}

Giuliani, Nicola ^{[1
,2
]}

机构：

[1] Univ Parma, Dept Med & Surg, Viale Antonio Gramsci 14, I-43126 Parma, Italy

[2] Univ Hosp Parma, Hematol & BMT Unit, Dept Onco Hematol, Parma, Italy

来源：

EJHAEM | 2024年 / 5卷 / 04期

关键词：

autologous stem cell transplantation; early relapse; high risk; multiple myeloma; RANDOMIZED-TRIAL; POOR SURVIVAL; AUTO-SCT; OUTCOMES; IMPACT; ERA;

D O I：

10.1002/jha2.924

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A portion of multiple myeloma (MM) patients relapse early or do not respond to first line treatment. Identification of possible clinical and or biological features of these patients remains an unmet medical need. In this study we assesed the predictive markers for early relapse MM, defined as a progressive disease that occurred within 18 months, from autologoust stem cell transplantation (ASCT) in MM patients who did not have primary refractory disease. 74 consecutive MM patients were included in the study that received intensive therapy with ASCT. The study was able to identify the main features of newly diagnosed ER MM patients eligible for ASCT identifying the IgA isotype and the R2-ISS score system as the main predictive prognostic factors for ER in this cohort of MM patients.

引用

页码：892 / 895

页数：4

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