Treatment of vascular leg ulcers with leukocyte- and platelet-rich fibrin (L-PRF): A systematic review

被引：1

作者：

Amin, Amirali Barzegar ^{[1
]}

Dorpmans, Dries ^{[1
]}

Mufty, Hozan ^{[1
,2
]}

Fourneau, Inge ^{[1
,2
]}

机构：

[1] Univ Hosp Leuven, Dept Vasc Surg, Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Vasc Surg, Herestr 49, B-3000 Leuven, Belgium

来源：

PHLEBOLOGY | 2024年 / 39卷 / 08期

关键词：

Platelet-rich fibrin; leg ulcer; wound healing; PLASMA PRP; GROWTH-FACTORS; RELEASE; PRGF;

D O I：

10.1177/02683555241256543

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Objectives: This systematic review aimed to assess the efficacy of Leukocyte- and Platelet-Rich Fibrin (L-PRF) for the treatment of vascular leg ulcers. Method: Following PRISMA guidelines, a literature search was done for studies where L-PRF was used to treat vascular leg ulcers. Results: Among six included articles, a total of 76 venous leg ulcers were treated with L-PRF. None of the studies included ulcers of arterial or lymphatic origin. Fifty-seven (75.0%) of the venous ulcers completely healed at end of follow-up. Mean time to complete healing was 6.7 weeks (SD = 5.0). All non-healed ulcers showed an important reduction in wound area. No adverse effects related to L-PRF therapy were reported. Conclusions: The results suggest that L-PRF could be a safe, simple to use and effective therapeutic option for the treatment of venous leg ulcers, however, caution is advised as the results are based on small sample sizes.

引用

页码：512 / 520

页数：9

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