Genomic Profiling for Predictive Treatment Strategies in Fibrotic Interstitial Lung Disease

被引：1

作者：

Perrotta, Fabio ^{[1
,2
]}

Zamparelli, Stefano Sanduzzi ^{[3
]}

D'Agnano, Vito ^{[1
,2
]}

Montella, Antonia ^{[1
,2
]}

Fomez, Ramona ^{[1
,2
]}

Pagliaro, Raffaella ^{[1
,2
]}

Schiattarella, Angela ^{[1
,2
]}

Cazzola, Mario ^{[4
]}

Bianco, Andrea ^{[1
,2
]}

Mariniello, Domenica Francesca ^{[5
]}

机构：

[1] Univ Campania L Vanvitelli, Dept Translat Med Sci, I-80131 Naples, Italy

[2] Monaldi Hosp, Unit Resp Med L Vanvitelli, AO Colli, I-80131 Naples, Italy

[3] A Cardarelli Hosp, Div Pneumol, I-80128 Naples, Italy

[4] Univ Roma Tor Vergata, Dept Expt Med, Unit Resp Med, I-00133 Rome, Italy

[5] AORN Monaldi Cotugno CTO, UOC Pneumotisiol Federico II, Piazzale Ettore Ruggieri, I-80131 Naples, Italy

来源：

BIOMEDICINES | 2024年 / 12卷 / 07期

关键词：

pharmacogenomics; interstitial lung diseases; idiopathic pulmonary fibrosis; antifibrotics; nintedanib; pirfenidone; precision medicine; IDIOPATHIC PULMONARY-FIBROSIS; NECROSIS-FACTOR-ALPHA; MUC5B PROMOTER POLYMORPHISM; MYCOPHENOLATE-MOFETIL; SYSTEMIC-SCLEROSIS; TREATMENT OUTCOMES; RANDOMIZED-TRIAL; TELOMERE LENGTH; GENE-EXPRESSION; TNF-ALPHA;

D O I：

10.3390/biomedicines12071384

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Idiopathic pulmonary fibrosis (IPF) has traditionally been considered the archetype of progressive fibrotic interstitial lung diseases (f-ILDs), but several other f-ILDs can also manifest a progressive phenotype. Integrating genomic signatures into clinical practice for f-ILD patients may help to identify patients predisposed to a progressive phenotype. In addition to the risk of progressive pulmonary fibrosis, there is a growing body of literature examining how pharmacogenomics influences treatment response, particularly regarding the efficacy and safety profiles of antifibrotic and immunomodulatory agents. In this narrative review, we discuss current studies in IPF and other forms of pulmonary fibrosis, including systemic autoimmune disorders associated ILDs, sarcoidosis and hypersensitivity pneumonitis. We also provide insights into the future direction of research in this complex field.

引用

页数：18

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