Major changes in prevalence and genotypes of rotavirus diarrhea in Beijing, China after RV5 rotavirus vaccine introduction

被引：2

作者：

Tian, Yi ^{[1
]}

Shen, Lingyu ^{[1
]}

Li, Weihong ^{[1
]}

Yan, Hanqiu ^{[1
]}

Fu, Jiamei ^{[1
]}

Liu, Baiwei ^{[1
]}

Wang, Yu ^{[1
]}

Jia, Lei ^{[1
]}

Li, Gang ^{[1
]}

Suo, Luodan ^{[1
]}

Zhang, Daitao ^{[1
]}

Gao, Zhiyong ^{[1
,2
]}

Wang, Quanyi ^{[1
,2
]}

机构：

[1] Beijing Municipal Ctr Dis Prevent & Control, Inst Infect Dis & Endem Dis Control, Beijing, Peoples R China

[2] 16 Hepingli Middle St, Beijing 100013, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2024年 / 96卷 / 05期

关键词：

acute diarrhea; genotype; group A rotavirus; vaccine; OUTBREAK; JAPAN; EFFICACY; SAFETY; STRAIN;

D O I：

10.1002/jmv.29650

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To analyze the epidemiological characteristics of group A rotavirus (RVA) diarrhea in Beijing between 2019 and 2022 and evaluate the effectiveness of the RV5 vaccine. Stool specimens were collected from patients with acute diarrhea, and RVA was detected and genotyped. The whole genome of RVA was sequenced by fragment amplification and Sanger sequencing. Phylogenetic trees were constructed using Bayesian and maximum likelihood methods. Descriptive epidemiological methods were used to analyze the characteristics of RVA diarrhea. Test-negative design was used to evaluate the vaccine effectiveness (VE) of the RV5. Compared with 2011-2018, RVA-positive rates in patients with acute diarrhea under 5 years of age and adults decreased significantly between 2019 and 2022, to 9.45% (249/634) and 3.66% (220/6016), respectively. The predominant genotype of RVA had changed from G9-VIP[8]-III between 2019 and 2021 to G8-VP[8]-III in 2022, and P[8] sequences from G8-VP[8]-III strains formed a new branch called P[8]-IIIb. The complete genotype of G8-VP[8]-III was G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. The VE of 3 doses of RV5 was 90.4% (95% CI: 28.8%-98.7%) against RVA diarrhea. The prevalence of RVA decreased in Beijing between 2019 and 2022, and the predominant genotype changed to G8P[8], which may be related to RV5 vaccination. Continuous surveillance is necessary to evaluate vaccine effectiveness and improve vaccine design.

引用

页数：14

共 35 条

[1] Disease burden and seasonal impact of improving rotavirus vaccine coverage in the United States: A modeling study [J].

Ai, Chin-En ;

Steele, Molly ;

Lopman, Benjamin .

PLOS ONE, 2020, 15 (02)

[2]

Bergman H., 2021, Cochrane DatabaseSystRev, V11

[3]

Bonkoungou Isidore Juste O, 2018, Vaccine, V36, P7170, DOI 10.1016/j.vaccine.2017.12.056

[4] Major Changes in Spatiotemporal Trends of US Rotavirus Laboratory Detections After Rotavirus Vaccine Introduction-2009-2021 [J].

Burnett, Eleanor ;

Parashar, Umesh D. ;

Winn, Amber ;

Curns, Aaron T. ;

Tate, Jacqueline E. .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2022, 41 (09) :759-763

[5] Predominance of DS-1-like G8P[8] rotavirus reassortant strains in children hospitalized with acute gastroenteritis in Thailand, 2018-2020 [J].

Chan-It, Wisoot ;

Chanta, Chulapong ;

Ushijima, Hiroshi .

JOURNAL OF MEDICAL VIROLOGY, 2023, 95 (06)

[6] An unusual outbreak of rotavirus G8P[8] gastroenteritis in adults in an urban community, Singapore, 2016 [J].

Chia, Gabriel ;

Ho, Hanley J. ;

Ng, Ching-Ging ;

Neo, Freddy Jun-Xian ;

Win, Mar-Kyaw ;

Cui, Lin ;

Leo, Yee-Sin ;

Chow, Angela .

JOURNAL OF CLINICAL VIROLOGY, 2018, 105 :57-63

[7] Aetiology and incidence of diarrhoea requiring hospitalisation in children under 5 years of age in 28 low-income and middle-income countries: findings from the Global Pediatric Diarrhea Surveillance network [J].

Cohen, Adam L. ;

Platts-Mills, James A. ;

Nakamura, Tomoka ;

Operario, Darwin J. ;

Antoni, Sebastien ;

Mwenda, Jason M. ;

Weldegebriel, Goitom ;

Rey-Benito, Gloria ;

de Oliveira, Lucia H. ;

Ortiz, Claudia ;

Daniels, Danni S. ;

Videbaek, Dovile ;

Singh, Simarjit ;

Njambe, Emmanuel ;

Sharifuzzaman, Mohamed ;

Grabovac, Varja ;

Nyambat, Batmunkh ;

Logronio, Josephine ;

Armah, George ;

Dennis, Francis E. ;

Seheri, Mapaseka L. ;

Magagula, Nokululeko ;

Mphahlele, Jeffrey ;

Fumian, Tulio M. ;

Maciel, Irene T. A. ;

Leite, Jose Paulo Gagliardi ;

Esona, Matthew D. ;

Bowen, Michael D. ;

Samoilovich, Elena ;

Semeiko, Galina ;

Abraham, Dilip ;

Giri, Sidhartha ;

Praharaj, Ira ;

Kang, Gagandeep ;

Thomas, Sarah ;

Bines, Julie ;

Liu, Na ;

Kyu, Hmwe H. ;

Doxey, Matthew ;

McQuade, Elizabeth T. Rogawski ;

McMurry, Timothy L. ;

Liu, Jie ;

Houpt, Eric R. ;

Tate, Jacqueline E. ;

Parashar, Umesh D. ;

Serhan, Fatima .

BMJ GLOBAL HEALTH, 2022, 7 (09)

[8] Emergence of unusual rotavirus G9P[4] and G8P[8] strains during post vaccination surveillance in Argentina, 2017-2018 [J].

Degiuseppe, Juan Ignacio ;

Andr, Juan .

INFECTION GENETICS AND EVOLUTION, 2021, 93

[9] Evidence of rotavirus vaccine impact in sub-Saharan Africa: Systematic review and meta-analysis [J].

Godfrey, Opolot ;

Zhang, Weidong ;

Amponsem-Boateng, Cecilia ;

Oppong, Timothy Bonney ;

Zhao, QingLin ;

Li, Dankang .

PLOS ONE, 2020, 15 (04)

[10] Distribution of rotavirus genotypes in Japan from 2015 to 2018: Diversity in genotypes before and after introduction of rotavirus vaccines [J].

Hoque, Sheikh Ariful ;

Khandoker, Nusrat ;

Thongprachum, Aksara ;

Khamrin, Pattara ;

Takanashi, Sayaka ;

Okitsu, Shoko ;

Nishimura, Shuichi ;

Kikuta, Hideaki ;

Yamamoto, Atsuko ;

Sugita, Kumiko ;

Baba, Tsuneyoshi ;

Kobayashi, Masaaki ;

Hayakawa, Satoshi ;

Mizuguchi, Masashi ;

Maneekarn, Niwat ;

Ushijima, Hiroshi .

VACCINE, 2020, 38 (23) :3980-3986

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