1,2,4-Triazole-conjugated Fluoroquinolones as Potential Candidates for New Antibacterial Agents

被引：0

作者：

Cebeci, Yildiz Uygun ^{[1
]}

Karaoglu, Senguel Alpay ^{[2
]}

机构：

[1] Kirklareli Univ, Dept Chem, Kirklareli, Turkiye

[2] Recep Tayyip Erdogan Univ, Dept Biol, Rize, Turkiye

来源：

LETTERS IN ORGANIC CHEMISTRY | 2024年 / 21卷 / 08期

关键词：

Fluoroquinolones; hybride molecule; triazole; mannich base; schiff base; antibacterial; MANNICH-BASES; ANTIMICROBIAL EVALUATION; DERIVATIVES; ANTICANCER; SCHIFF; DESIGN; ORGANOCATALYSIS; QUINOLONES; CHEMISTRY; ALDOL;

D O I：

10.2174/0115701786270260231215101046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, synthesis of 1,2,4 triazole-fluoroquinolone hybrid compounds was realized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures of all synthesized compounds. The antimicrobial activities of all compounds were investigated, and it was observed that 7a-d compounds, which are mannich bases, showed excellent activity.

引用

收藏

页码：669 / 676

页数：8

相关论文

共 59 条

[1] Theory of asymmetric organocatalysis of aldol and related reactions: Rationalizations and predictions [J].

Allemann, C ;

Gordillo, R ;

Clemente, FR ;

Cheong, PHY ;

Houk, KN .

ACCOUNTS OF CHEMICAL RESEARCH, 2004, 37 (08) :558-569

[2] Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties [J].

Almajan, Gabriela Laura ;

Barbuceanu, Stefania-Felicia ;

Almajan, Eva-Ruxandra ;

Draghici, Constantin ;

Saramet, Gabriel .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (07) :3083-3089

[3] Microwave assisted regioselective synthesis of novel pyrazoles and pyrazolopyridazines via fluorine containing building blocks [J].

Althagafi, Ismail I. ;

Shaaban, Mohamed R. .

JOURNAL OF MOLECULAR STRUCTURE, 2017, 1142 :122-129

[4] Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents [J].

Ammar, Usama M. ;

Abdel-Maksoud, Mohammed S. ;

Oh, Chang-Hyun .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 158 :144-166

[5]

[Anonymous], 1999, Angew. Chem, V111, P166

[6] Convenient one pot synthesis and antimicrobial evaluation of some new Mannich bases carrying 4-methylthiobenzyl moiety [J].

Ashok, Mithun ;

Holla, Bantwal Shivarama ;

Poojary, Boja .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (08) :1095-1101

[7] Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities [J].

Bayrak, Hacer ;

Demirbas, Ahmet ;

Karaoglu, Senguel Alpay ;

Demirbas, Neslihan .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (03) :1057-1066

[8] Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4-aminoquinoline-1,3,5-triazine derivatives [J].

Bhat, Hans Raj ;

Masih, Anup ;

Shakya, Anshul ;

Ghosh, Surajit Kumar ;

Singh, Udaya Pratap .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (01) :390-399

[9] Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors [J].

Bianco, Maria da Conceicao Avelino Dias ;

Marinho, Debora Inacio Leite Firmino ;

Hoelz, Lucas Villas Boas ;

Bastos, Monica Macedo ;

Boechat, Nubia .

PHARMACEUTICALS, 2021, 14 (09)

[10] Synthesis and Characterization of Some Azole Derivatives as Potential Biological and Anticancer Agents [J].

Cebeci, Yildiz Uygun ;

Ceylan, Sule ;

Altun, Muhammed ;

Karaoglu, Sengul Alpay .

CHEMISTRYSELECT, 2023, 8 (12)

← 1 2 3 4 5 6 →