"Especially Being Homeless, They Just Think You're Infected with COVID or Something": A Qualitative Exploration of the COVID-19 Pandemic's Impact on People Experiencing Homelessness With a History of Injection Drug Use in Baltimore, Maryland

People experiencing homelessness with a substance use disorder are a highly structurally vulnerable population, facing a unique burden of compounding stigma, discrimination, and adverse health outcomes. Evidence remains mixed on best practices for housing interventions designed to meet the needs of this population. Ten people with a history of injection drug use experiencing homelessness during the COVID-19 pandemic were interviewed between July 2021 and February 2022 in Baltimore, Maryland. Thematic analysis was used to characterize the pandemic's impact on their resource access, housing, and substance use. Participants highlighted substantial challenges resulting from structural changes during the pandemic, including limits on income-generating opportunities and resource access, and increases in experiences of stigma and discrimination. However, several individuals reported decreased substance use in response to changes to their housing status, with those placed in secure housing attributing their decreased use to this change. These accounts can help guide housing and social support interventions best suited to meet the unique needs of people experiencing homelessness with substance use disorders.