Inhibition of astrocytic glycine transporter-1: friend or foe for ameliorating NMDA receptor hypofunction?

被引:0
作者
Singer, Philipp [1 ]
Yee, Benjamin K. [2 ,3 ]
机构
[1] Roche Diagnost Int AG, Rotkreuz, Switzerland
[2] Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China
[3] Hong Kong Polytech Univ, Mental Hlth Res Ctr, Kowloon, Hong Kong, Peoples R China
关键词
antipsychotics; glycine reuptake; glycine-B site; neuron-glial interaction; NMDA receptors; schizophrenia; NEGATIVE SYMPTOMS; DOUBLE-BLIND; THERAPEUTIC TARGET; N-METHYLGLYCINE; SERINE RACEMASE; SCHIZOPHRENIA; GLUTAMATE; NEUROTRANSMISSION; BITOPERTIN; RELEASE;
D O I
10.3389/fncel.2024.1389718
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
[No abstract available]
引用
收藏
页数:6
相关论文
共 45 条
[1]   Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior [J].
Basu, A. C. ;
Tsai, G. E. ;
Ma, C-L ;
Ehmsen, J. T. ;
Mustafa, A. K. ;
Han, L. ;
Jiang, Z. I. ;
Benneyworth, M. A. ;
Froimowitz, M. P. ;
Lange, N. ;
Snyder, S. H. ;
Bergeron, R. ;
Coyle, J. T. .
MOLECULAR PSYCHIATRY, 2009, 14 (07) :719-727
[2]   Glycine transporters: essential regulators of synaptic transmission [J].
Betz, H ;
Gomeza, J ;
Armsen, W ;
Scholze, P ;
Eulenburg, V .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 :55-58
[3]   Bitopertin in Negative Symptoms of Schizophrenia-Results From the Phase III FlashLyte and DayLyte Studies [J].
Bugarski-Kirola, Dragana ;
Blaettler, Thomas ;
Arango, Celso ;
Fleischhacker, Wolfgang W. ;
Garibaldi, George ;
Wang, Alice ;
Dixon, Mark ;
Bressan, Rodrigo A. ;
Nasrallah, Henry ;
Lawrie, Stephen ;
Napieralski, Julie ;
Ochi-Lohmann, Tania ;
Reid, Carol ;
Marder, Stephen R. .
BIOLOGICAL PSYCHIATRY, 2017, 82 (01) :8-16
[4]   SCHIZOPHRENIA - A SUBCORTICAL NEUROTRANSMITTER IMBALANCE SYNDROME [J].
CARLSSON, M ;
CARLSSON, A .
SCHIZOPHRENIA BULLETIN, 1990, 16 (03) :425-432
[5]   Glycine transporter-1 inhibitors: a patent review (2011-2016) [J].
Cioffi, Christopher L. .
EXPERT OPINION ON THERAPEUTIC PATENTS, 2018, 28 (03) :197-210
[6]   Glutamate and schizophrenia: beyond the dopamine hypothesis. [J].
Joseph T. Coyle .
Cellular and Molecular Neurobiology, 2006, 26 (4) :365-384
[7]   Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse [J].
Coyle, Joseph T. ;
Ruzicka, W. Brad ;
Balu, Darrick T. .
AMERICAN JOURNAL OF PSYCHIATRY, 2020, 177 (12) :1119-1128
[8]   Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia [J].
Dogra, Shalini ;
Conn, P. Jeffrey .
MOLECULAR PHARMACOLOGY, 2022, 101 (05) :275-285
[9]  
Fleischhacker WW, 2021, LANCET PSYCHIAT, V8, P191, DOI 10.1016/S2215-0366(20)30513-7
[10]   Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality [J].
Gomeza, J ;
Ohno, K ;
Hülsmann, S ;
Armsen, W ;
Eulenburg, V ;
Richter, DW ;
Laube, B ;
Betz, H .
NEURON, 2003, 40 (04) :797-806