Exploring the latent cognitive structure in schizophrenia: implications for antipsychotic treatment responses

被引：0

作者：

Wang, Weiyan ^{[1
,2
]}

Peng, Xingjie ^{[1
,2
]}

Hei, Gangrui ^{[3
]}

Long, Yujun ^{[1
,2
]}

Xiao, Jingmei ^{[1
,2
]}

Shao, Tiannan ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Yang, Ye ^{[1
,2
]}

Wang, Xiaoyi ^{[1
,2
]}

Song, Chuhan ^{[1
,2
]}

Huang, Yuyan ^{[1
,2
]}

Cai, Jingda ^{[1
,2
]}

Huang, Jing ^{[1
,2
]}

Kang, Dongyu ^{[1
,2
]}

Wang, Ying ^{[4
]}

Zhao, Jingping ^{[1
,2
]}

Tang, Hui ^{[1
,2
]}

Wu, Renrong ^{[1
,2
]}

机构：

[1] Cent South Univ, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China

[2] Cent South Univ, Natl Ctr Mental Disorders, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China

[3] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R China

[4] Cent South Univ, Mental Hlth Ctr, Xiangya Hosp, Changsha 410011, Hunan, Peoples R China

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2025年 / 275卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Latent profile analysis (LPA); Schizophrenia; Cognitive impairment; Antipsychotic treatment responses; PANSS reduction rate; CLUSTER-ANALYSIS; HETEROGENEITY; ONSET; RELIABILITY; PSYCHOSIS; SELECTION; PROFILES; BATTERY; NUMBER; AGE;

D O I：

10.1007/s00406-024-01828-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Individuals diagnosed with schizophrenia present diverse degrees and types of cognitive impairment, leading to variations in responses to antipsychotic treatments. Understanding the underlying cognitive structures is crucial for assessing this heterogeneity. Utilizing latent profile analysis (LPA) enables the delineation of latent categories of cognitive function. Integrating this approach with a dimensional perspective allows for the exploration of the relationship between cognitive function and treatment response. Methods This study examined 647 patients from two distinct cohorts. Utilizing LPA within the discovery cohort (n = 333) and the replication cohort (n = 314), latent subtypes were identified categorically. The stability of cognitive structures was evaluated employing Latent Transition Analysis (LTA). The relationship between cognitive function and treatment response were investigated by comparing Positive and Negative Syndrome Scale (PANSS) reduction rates across diverse cognitive subtypes. Furthermore, dimensional insights were gained through correlation analyses between cognitive tests and PANSS reduction rates. Results In terms of categorical, individuals diagnosed with schizophrenia can be categorized into three distinct subtypes: those 'without cognitive deficit', those 'with mild-moderate cognitive 'eficit', and those 'with moderate-severe cognitive deficit'. There are significant differences in PANSS reduction rates among patients belonging to these subtypes following antipsychotic treatment (p < 0.05). Furthermore, from a dimensional perspective, processing speed at baseline is positively correlated with PANSS score reduction rates at week 8/week 10 (p < 0.01). Conclusions Our findings have unveiled the latent subtypes of cognitive function in schizophrenia, illuminating the association between cognitive function and responses to antipsychotic treatment from both categorical and dimensional perspectives.

引用

页码：691 / 699

页数：9

共 41 条

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