Bridging metabolic syndrome and cognitive dysfunction: role of astrocytes

被引：4
作者：
Li, Zihan [1 ,2 ]
Jiang, Ya-yi [1 ,2 ]
Long, Caiyi [1 ,2 ]
Peng, Xi [1 ,2 ]
Tao, Jiajing [1 ,2 ]
Pu, Yueheng [1 ,2 ]
Yue, Rensong [1 ,2 ]
机构：
[1] Hosp Chengdu Univ Tradit Chinese Med, Dept Endocrinol, Chengdu, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Clin Med Sch, Chengdu, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2024年 / 15卷
关键词：
metabolic syndrome; cognitive dysfunction; astrocytes; immunometabolism; neurodegeneration; BETA/NF-KAPPA-B; CULTURED ASTROCYTES; INFLAMMATORY MARKERS; INSULIN-RESISTANCE; ANGIOTENSIN-II; BLOOD-PRESSURE; BRAIN; GLUCOSE; DIET; RAT;
D O I：
10.3389/fendo.2024.1393253
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Metabolic syndrome (MetS) and cognitive dysfunction pose significant challenges to global health and the economy. Systemic inflammation, endocrine disruption, and autoregulatory impairment drive neurodegeneration and microcirculatory damage in MetS. Due to their unique anatomy and function, astrocytes sense and integrate multiple metabolic signals, including peripheral endocrine hormones and nutrients. Astrocytes and synapses engage in a complex dialogue of energetic and immunological interactions. Astrocytes act as a bridge between MetS and cognitive dysfunction, undergoing diverse activation in response to metabolic dysfunction. This article summarizes the alterations in astrocyte phenotypic characteristics across multiple pathological factors in MetS. It also discusses the clinical value of astrocytes as a critical pathologic diagnostic marker and potential therapeutic target for MetS-associated cognitive dysfunction.
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页数：18
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共 225 条
  • [1] Long-Term Exposure of Cultured Astrocytes to High Glucose Impact on Their LPS-Induced Activation
    Abdyeva, Ayna
    Kurtova, Ekaterina
    Savinkova, Irina
    Galkov, Maksim
    Gorbacheva, Liubov
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (02)
  • [2] Alteration of glial fibrillary acidic proteins immunoreactivity in astrocytes of the spinal cord diabetic rats
    Afsari, Zainab H.
    Renno, Waleed M.
    Abd-El-Basset, E.
    [J]. ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2008, 291 (04): : 390 - 399
  • [3] Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    Alberti, K. G. M. M.
    Eckel, Robert H.
    Grundy, Scott M.
    Zimmet, Paul Z.
    Cleeman, James I.
    Donato, Karen A.
    Fruchart, Jean-Charles
    James, W. Philip T.
    Loria, Catherine M.
    Smith, Sidney C., Jr.
    [J]. CIRCULATION, 2009, 120 (16) : 1640 - 1645
  • [4] The metabolic syndrome - a new worldwide definition
    Alberti, KGMM
    Zimmet, P
    Shaw, J
    [J]. LANCET, 2005, 366 (9491) : 1059 - 1062
  • [5] White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging
    Alfaro, Freddy J.
    Gavrieli, Anna
    Saade-Lemus, Patricia
    Lioutas, Vasileios-Arsenios
    Upadhyay, Jagriti
    Novak, Vera
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 78 : 52 - 68
  • [6] Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress
    An, Ji-Ren
    Liu, Jun-Tong
    Gao, Xiao-Meng
    Wang, Qing-Feng
    Sun, Gui-Yan
    Su, Jia-Nan
    Zhang, Chi
    Yu, Jia-Xiang
    Yang, Yu-Feng
    Shi, Yan
    [J]. FRONTIERS IN CELLULAR NEUROSCIENCE, 2023, 17
  • [7] [Anonymous], 1999, Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation-Part 1: Diagnosis and Classification of Diabetes Mellitus
  • [8] Microbiota impacts on chronic inflammation and metabolic syndrome-related cognitive dysfunction
    Arnoriaga-Rodriguez, Maria
    Fernandez-Real, Jose Manuel
    [J]. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2019, 20 (04) : 473 - 480
  • [9] Ultrastructural view of astrocyte arborization, astrocyte-astrocyte and astrocyte-synapse contacts, intracellular vesicle-like structures, and mitochondrial network
    Aten, Sydney
    Kiyoshi, Conrad M.
    Arzola, Emily P.
    Patterson, Jeremy A.
    Taylor, Anne T.
    Du, Yixing
    Guiher, Ally M.
    Philip, Merna
    Camacho, Elizabeth Gerviacio
    Mediratta, Devin
    Collins, Kelsey
    Boni, Kirsten
    Garcia, Silvana A.
    Kumar, Rahul
    Drake, Aiden N.
    Hegazi, Ahlam
    Trank, Lindsey
    Benson, Emily
    Kidd, Grahame
    Terman, David
    Zhou, Min
    [J]. PROGRESS IN NEUROBIOLOGY, 2022, 213
  • [10] Cerebral Haemodynamics: Effects of Systemic Arterial Pulsatile Function and Hypertension
    Avolio, Alberto
    Kim, Mi Ok
    Adji, Audrey
    Gangoda, Sumudu
    Avadhanam, Bhargava
    Tan, Isabella
    Butlin, Mark
    [J]. CURRENT HYPERTENSION REPORTS, 2018, 20 (03)
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