Effects of Cyclophosphamide Pulse Therapy on the Clinical and Histopathological Findings, Particularly Crescent Formation, in a Patient with Adult-onset Steroid-refractory Henoch-Schonlein Purpura Nephritis

被引：5

作者：

Tanaka, Yusuke ^{[1
]}

Nakashima, Yuri ^{[2
]}

Mima, Toru ^{[2
]}

Ohya, Masaki ^{[2
]}

Yamamoto, Shuto ^{[1
]}

Kobayashi, Sou ^{[3
]}

Masumoto, Asuka ^{[2
]}

Masumoto, Koji ^{[4
]}

Yano, Takurou ^{[3
]}

Moribata, Mari ^{[2
]}

Yoshimoto, Wataru ^{[5
]}

Yamanaka, Shintaro ^{[2
]}

Koreeda, Daisuke ^{[2
]}

Hanba, Yoshiyuki ^{[2
]}

Tatsuta, Koichi ^{[2
]}

Sakaguchi, Toshifumi ^{[3
]}

Negi, Shigeo ^{[2
]}

Shigematsu, Takashi ^{[2
]}

机构：

[1] Shingu Municipal Med Ctr, Dept Nephrol & Dialysis, Shingu, Japan

[2] Wakayama Med Univ, Div Nephrol, Dept Internal Med, Wakayama, Japan

[3] Rinku Gen Med Ctr, Dept Nephrol, Blood Purificat Ctr, Osaka, Japan

[4] Social Insurance Kinan Hosp, Dept Nephrol & Dialysis, Tanabe, Japan

[5] Naga Hosp, Naga, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 17期

关键词：

histopathology; Henoch-Schonlein purpura; glomerular nephritis; renal biopsy; PROGNOSTIC-FACTORS; CHILDREN; AZATHIOPRINE; PREDNISONE; DISEASE;

D O I：

10.2169/internalmedicine.54.4330

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 29-year-old woman was diagnosed with Henoch-Schonlein purpura nephritis (HSPN) based on the presence of purpura and histopathological findings showing crescent formation, mesangial proliferation and IgA deposition in the glomerular mesangium. She was treated with high-dose steroids; however, the nephritic syndrome persisted. Therefore, we diagnosed her with steroid-resistant HSPN and decided to add treatment with cyclosphamide pulse therapy. After one year of treatment, the histopathological findings, including crescent formation and IgA deposition, improved, as confirmed on a renal biopsy, and the patient fulfilled the criteria for complete remission. Cyclophosphamide pulse therapy may be considered an effective treatment for intractable HSPN.

引用

页码：2207 / 2211

页数：5

共 22 条

[21] Severe Henoch-Schonlein nephritis: resolution with azathioprine and steroids
Singh, S
Devidayal
Kumar, L
Joshi, K
Minz, RW
Datta, U
[J]. RHEUMATOLOGY INTERNATIONAL, 2002, 22 (04) : 133 - 137
[22] Early treatment with oral immunosuppressants in severe proteinuric purpura nephritis
Tanaka, H
Suzuki, K
Nakahata, T
Ito, E
Waga, S
[J]. PEDIATRIC NEPHROLOGY, 2003, 18 (04) : 347 - 350

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