Antimicrobial Peptide-Modified Liquid Metal Nanomaterials for Enhanced Antibacterial Photothermal Therapy

被引：1

作者：

Wang, Bo ^{[1
]}

Chen, Sen ^{[2
]}

Feng, Weichen ^{[3
]}

Shan, Xiaohui ^{[3
]}

Zhu, Xiyu ^{[3
]}

Yuan, Ruizhi ^{[3
]}

Cao, Yingjie ^{[3
]}

Fan, Linlin ^{[4
]}

Yuan, Bo ^{[1
]}

Wang, Hongzhang ^{[5
]}

Zhou, Gang ^{[1
]}

Liu, Jing ^{[3
,6
]}

机构：

[1] Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing 100083, Peoples R China

[2] Nanjing Univ Aeronaut & Astronaut, Minist Educ, Key Lab Intelligent Nano Mat & Devices, Inst Frontier Sci, Nanjing 210016, Peoples R China

[3] Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China

[4] Beijing Jishuitan Hosp, Beijing Res Inst Orthopaed & Traumatol, Beijing 100035, Peoples R China

[5] Tsinghua Shenzhen Int Grad Sch, Ctr Double Helix, Shenzhen 518055, Peoples R China

[6] Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

来源：

ADVANCED ENGINEERING MATERIALS | 2024年 / 26卷 / 12期

基金：

中国国家自然科学基金;

关键词：

antimicrobial peptides; core-shell structured nanomaterials; liquid metals; photothermal therapy; NANOPARTICLES; VANCOMYCIN; ABLATION; BACTERIA; AGENT;

D O I：

10.1002/adem.202400189

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The misuse of antibiotics has led to antibiotic-resistant "superbugs," prompting the exploration of alternative antibacterial strategies. This study focuses on the promising avenue of photothermal therapy (PTT). Despite numerous advantages, the clinical applicability of PTT as a sole sterilization strategy is hindered by the necessity for higher temperatures, potentially causing harm to healthy tissues. To overcome this challenge, this study introduces antimicrobial peptides (AMPs) to modify the surface of gallium-based liquid metal (LM) nano-antimicrobial agents, thereby enhancing their photothermal antibacterial effects within a lower temperature range. First, a novel LM composite nanomaterial, LM@AMP nanoparticles, is synthesized through a sonication process involving 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)], AMP, and LM in an aqueous solution. Herein, AMPs not only contribute to the structural stability of LM nanoparticles but also enhance their selective interaction with bacterial cell membranes. Then, a thorough characterization of LM@AMP nanoparticles is performed, encompassing analyses through electron microscopy, determination of particle size, and assessment of zeta potential. Moreover, the exceptional photothermal properties exhibited by these nanoparticles are validated. Finally, this investigation demonstrates that LM@AMP nanoparticles selectively target bacterial cell membranes, showcasing efficient bactericidal effects (near 100%) at relatively low temperatures under near-infrared irradiation. Antibiotic misuse drives exploration of alternative antibacterial strategies like photothermal therapy. To mitigate damage to healthy tissues at high temperatures, liquid metal nano-antimicrobial agents with antimicrobial peptides are modified, which exhibit exceptional photothermal properties, selectively targeting bacterial cell membranes, and efficient bactericidal effects (near 100%) at lower temperatures. This innovative approach shows promise in addressing bacterial infections.image (c) 2024 WILEY-VCH GmbH

引用

页数：8