Venous thromboembolic events following cytoreductive surgery for lower gastrointestinal neoplasia

被引：0

作者：

Guirgis, Mina ^{[1
,2
]}

Keelan, Simon ^{[1
,2
]}

McEntee, Philip ^{[1
,2
]}

Han, Margaret ^{[1
,2
]}

Moroz, Paul ^{[1
,2
,3
,4
]}

机构：

[1] Joondalup Hlth Campus, Dept Gen Surg, Perth, WA, Australia

[2] Corner Grant Blvd & Shenton Ave, Joondalup, WA 6027, Australia

[3] Joondalup Hlth Campus, Western Australian Peritonect Serv, Perth, WA, Australia

[4] Joondalup Private Hosp, Specialist Med Ctr East, Suite 24-26,Level 2,60 Shenton Ave, Joondalup, WA 6027, Australia

来源：

SURGERY IN PRACTICE AND SCIENCE | 2024年 / 18卷

关键词：

Cytoreduction surgical procedures; Appendiceal neoplasms; Pseudomyxoma peritonei; Colorectal cancer; Thromboembolism; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; BLOOD-TRANSFUSION; PROPHYLAXIS; CANCER; PERITONECTOMY; COMPLICATIONS; MULTICENTER; MANAGEMENT; MORBIDITY; MORTALITY;

D O I：

10.1016/j.sipas.2024.100257

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Introduction: Cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) represent a high-risk for venous thromboembolism (VTE) due to malignancy, prolonged surgery and immobility. We investigated the incidence of and risk factors for VTE following CRS/IPC. Materials and methods: Data was analysed on 130 CRS/IPC performed over a 6-year period at a single centre, the Western Australian Peritonectomy Service (WAPS), on lower gastrointestinal neoplasia: pseudomyxoma peritoneii (PMP), colorectal cancer (CRC) and appendix cancer (AC). Data was analysed by univariate and multivariate logistic regression to identify risk factors for VTE. Results: 31 patients (24%) experienced a VTE. The percentages of VTE among patients with PMP (n = 50), CRC (n = 53) and AC (n = 27) were 36%, 17% and 15% respectively. 60% of these cases were asymptomatic. The odds of VTE were higher for PMP patients than in patients with a other histopathology (OR=2.9, p = 0.01). Other significant risk factors for VTE on univariate analysis were PCI (OR=1.07, p = 0.001), pelvic dissection (OR=5.52, p = 0.001) and operation time (OR=1.36, p = 0.001). Conclusion: This study demonstrates high rates of VTE in patients undergoing CRS/IPC. Patients with PMP have a three-fold higher risk of VTE compared to other malignancies (CRC+AC). As most VTE cases were asymptomatic, aggressive early investigation and intervention is indicated for patients undergoing CRS/IPC.

引用

页数：5