The Effect of Antibacterial-Osteogenic Surface Modification on the Osseointegration of Titanium Implants: A Static and Dynamic Strategy

被引：8

作者：

Cui, Chenying ^{[1
,2
]}

Zhao, Yifan ^{[1
,2
]}

Bai, Ziyang ^{[1
,2
]}

Yan, Jingyu ^{[1
,2
]}

Qin, Danlei ^{[1
,2
]}

Peng, Hongyi ^{[1
,2
]}

Liu, Yingyu ^{[1
,2
]}

Tong, Jiahui ^{[1
,2
]}

Sun, Lingxiang ^{[1
,2
]}

Wu, Xiuping ^{[1
,2
]}

Li, Bing ^{[1
,2
]}

机构：

[1] Shanxi Med Univ, Sch & Hosp Stomatol, Taiyuan 030001, Shanxi, Peoples R China

[2] Shanxi Prov Key Lab Oral Dis Prevent & New Mat, Taiyuan 030001, Shanxi, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2024年 / 10卷 / 07期

关键词：

Titanium; Antibacterial; Static modification; Dynamic responsive; Osseointegration; METAL-ORGANIC FRAMEWORKS; IN-VITRO; MACROPHAGE POLARIZATION; ENHANCED OSTEOGENESIS; BACTERIAL-INFECTION; SIGNALING PATHWAYS; GOLD NANOPARTICLES; CHIMERIC PEPTIDES; BONE; COATINGS;

D O I：

10.1021/acsbiomaterials.3c01756

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Titanium (Ti) and its alloys are widely used biomaterials in bone repair. Although these biomaterials possess stable properties and good biocompatibility, the high elastic modulus and low surface activity of Ti implants have often been associated with infection, inflammation, and poor osteogenesis. Therefore, there is an urgent need to modify the surface of Ti implants, where changes in surface morphology or coatings loading can confer specific functions to help them adapt to the osseointegration formation phase and resist bacterial infection. This can further ensure a healthy microenvironment for bone regeneration as well as the promotion of immunomodulation, angiogenesis, and osteogenesis. Therefore, in this review, we evaluated various functional Ti implants after surface modification, both in terms of static modifications and dynamic response strategies, mainly focusing on the synergistic effects of antimicrobial activities and functionalized osteogenic. Finally, the current challenges and future perspectives are summarized to provide innovative and effective solutions for osseointegration and bone defect repair.

引用

页码：4093 / 4113

页数：21

共 181 条

[41] BIOMATERIAL-CENTERED INFECTION - MICROBIAL ADHESION VERSUS TISSUE INTEGRATION [J].