The neuronal cilium - a highly diverse and dynamic organelle involved in sensory detection and neuromodulation

被引：11

作者：

Jurisch-Yaksi, Nathalie ^{[1
]}

Wachten, Dagmar ^{[2
]}

Gopalakrishnan, Jay ^{[3
,4
]}

机构：

[1] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Clin & Mol Med IKOM, Erling Skalgssons Gate 1, N-7491 Trondheim, Norway

[2] Univ Bonn, Inst Innate Immun, Med Fac, Dept Biophys Imaging, Venusberg Campus 1, D-53127 Bonn, Germany

[3] Heinrich Heine Univ, Univ Hosp, Inst Human Genet, D-40225 Dusseldorf, Germany

[4] Friedrich Schiller Univ Jena, Univ Klinikum Jena, Inst Human Genet, D-07740 Jena, Germany

来源：

TRENDS IN NEUROSCIENCES | 2024年 / 47卷 / 05期

基金：

芬兰科学院;

关键词：

POSTTRANSLATIONAL MODIFICATIONS; HAIR-CELLS; ADCY3; LOCALIZATION; PROTEOMICS; RECEPTORS; EVOLUTION; PATHWAYS; CILIARY; CHANNEL;

D O I：

10.1016/j.tins.2024.03.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cilia are fascinating organelles that act as cellular antennae, sensing the cellular environment. Cilia gained significant attention in the late 1990s after their dysfunction was linked to genetic diseases known as ciliopathies. Since then, several breakthrough discoveries have uncovered the mechanisms underlying cilia biogenesis and function. Like most cells in the animal kingdom, neurons also harbor cilia, which are enriched in neuromodulatory receptors. Yet, how neuronal cilia modulate neuronal physiology and animal behavior remains poorly understood. By comparing ciliary biology between the sensory and central nervous systems (CNS), we provide new perspectives on the functions of cilia in brain physiology.

引用

页码：383 / 394

页数：12

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