Sonic hedgehog expression in steatohepatitic hepatocellular carcinoma and its clinicopathological significance

被引：1

作者：

Kusano, Hironori ^{[1
,2
]}

Ogasawara, Sachiko ^{[1
]}

Omuraya, Minori ^{[3
]}

Okudaira, Masayuki ^{[4
]}

Mizuochi, Shinji ^{[1
]}

Mihara, Yutaro ^{[1
]}

Kinjo, Yoshinao ^{[1
]}

Yano, Yuta ^{[1
]}

Nakayama, Masamichi ^{[1
]}

Kondo, Reiichiro ^{[1
]}

Naito, Yoshiki ^{[5
]}

Akiba, Jun ^{[6
]}

Nakashima, Osamu ^{[7
]}

Yano, Hirohisa ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Pathol, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan

[2] NHO Kokura Med Ctr, Dept Clin Lab, Kitakyushu, Fukuoka 8028533, Japan

[3] Omuta City Hosp, Omuta, Fukuoka 8368567, Japan

[4] NHO Nagasaki Med Ctr, Omura, Fukuoka 8560835, Japan

[5] Kurume Univ Hosp, Dept Clin Lab Med, Kurume, Fukuoka 8300011, Japan

[6] Kurume Univ Hosp, Dept Diagnost Pathol, Kurume, Fukuoka 8300011, Japan

[7] St Marys Hosp, Dept Clin Lab, Kurume, Fukuoka 8308543, Japan

来源：

ONCOLOGY LETTERS | 2024年 / 28卷 / 03期

关键词：

hedgehog signaling pathway; sonic hedgehog; hepatocellular carcinoma; steatohepatitic hepatocellular carcinoma; steatohepatitis; primary liver cancer; SIGNALING PATHWAY; ACTIVATION; PROGNOSIS;

D O I：

10.3892/ol.2024.14575

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hedgehog (Hh) signaling pathway dysregulation is involved in the pathogenesis of metabolic dysfunction-associated steatohepatitis, and the sonic Hh (SHh) protein, a pivotal molecule in the Hh pathway, is expressed in ballooned hepatocytes. The present study aimed to investigate the clinicopathological significance of SHh expression in steatohepatitic hepatocellular carcinoma (SH-HCC). Reverse transcription-quantitative polymerase chain reaction and immunohistochemistry were performed to examine SHh gene and SHh protein expression in SH-HCC. Additionally, patients with conventional HCC (C-HCC) were included in the control group. Comparisons of patient and tumor characteristics were also performed. The prevalence of SH-HCC was 3% in the whole cohort, and it was significantly associated with a high prevalence of diabetes mellitus. SHh mRNA was detected in all patients with SH-HCC, but not in 23% of patients with C-HCC. Notably, SHh mRNA expression was not significantly different between patients with SH-HCC and those with C-HCC; however, high SHh protein expression was significantly more frequent in SH-HCC patients than in those with C-HCC. Although the prognosis was not significantly different between the SH-HCC and C-HCC groups, high SHh protein expression was an independent poor prognostic factor for HCC. In conclusion, SHh could potentially serve as a therapeutic target for patients with HCC.

引用

页数：6

共 26 条

[21] The Prognostic Significance and Therapeutic Potential of Hedgehog Signaling in Intrahepatic Cholangiocellular Carcinoma [J].