Neural stem cell-derived exosomes: a cell-free transplant for potential cure of neurological diseases

被引：1

作者：

Huang, Jiajun ^{[1
]}

Wang, Wei ^{[1
]}

Lin, Wentong ^{[2
]}

Cai, Hengsen ^{[3
]}

Zhu, Zhihan ^{[1
]}

Ahmed, Waqas ^{[4
]}

Zhang, Qiankun ^{[1
]}

Liu, Jiale ^{[1
]}

Zhang, Yifan ^{[1
]}

Li, Rong ^{[1
]}

Li, Zhinuo ^{[1
]}

Khan, Ahsan Ali ^{[5
]}

Lu, Deng ^{[3
]}

Hu, Yong ^{[6
]}

Chen, Lukui ^{[1
]}

机构：

[1] Southern Med Univ, Hosp Integrated Tradit Chinese & Western Med, Dept Neurosurg, Guangzhou 510310, Peoples R China

[2] Chaozhou Hosp Tradit Chinese Med, Dept Orthopaed, Chaozhou 521011, Peoples R China

[3] Second Peoples Hosp Pingnan, Dept Neurosurg, Pingnan 537300, Peoples R China

[4] Southeast Univ, Sch Med, Dept Neurol, Nanjing 210009, Peoples R China

[5] Aga Khan Univ, Sect Neurosurg, Karachi 74800, Pakistan

[6] Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong 999077, Peoples R China

来源：

BIOCELL | 2024年 / 48卷 / 10期

基金：

国家重点研发计划;

关键词：

Stem cells; Exosomes; Nervous system diseases; Neural regeneration; Neural restoration; Cell-free therapy; ISCHEMIA-REPERFUSION INJURY; SPINAL-CORD-INJURY; NF-KAPPA-B; EXTRACELLULAR VESICLES; PROGENITOR CELLS; DELIVERY; NEUROGENESIS; THERAPY; BRAIN; NEUROINFLAMMATION;

D O I：

10.32604/biocell.2024.053148

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Degeneration and death of nerve cells are inevitable with the occurrence and progression of nervous system disorders. Researchers transplanted neural stem cells into relevant areas, trying to solve the difficulty of neural cell loss by differentiating neural stem cells into various nerve cells. In recent years, however, studies have shown that transplanted neural stem cells help neural tissues regenerate and return to normal through paracrine action rather than just replacing cells. Exosomes are essential paracrine mediators, which can participate in cell communication through substance transmission. In this regard, this review mainly discusses the current research progress of neural stem cell-derived exosomes. This paper mainly introduces the self-regulation of neural stem cells (NSCs)-derived exosomes on neural stem cells to clarify the role of NSCs-derived exosomes in the nervous system; the therapeutic effect of NSCs-derived exosomes on various neurological diseases; introduces different studies of NSCs-derived exosomes, showing more in-depth research results of NSCs-derived exosomes. It presents some ideas to provide a reference for subsequent research on neural stem cell-derived exosomes.

引用

页码：1405 / 1418

页数：14

共 92 条

[51] Effects of neural stem cell-derived extracellular vesicles on neuronal protection and functional recovery in the rat model of middle cerebral artery occlusion [J].