Polyaromatic Hydrocarbon-Functionalized 2D MXene-Based 3D Porous Antifouling Nanocomposite with Long Shelf Life for High-Performance Electrochemical Immunosensor Applications

被引：2

作者：

Reza, Md Selim ^{[1
,2
]}

Sharifuzzaman, Md ^{[1
,2
]}

Asaduzzaman, Md ^{[1
,2
]}

Islam, Zahidul ^{[1
,2
]}

Lee, Yeyeong ^{[1
,2
]}

Kim, Dongyun ^{[1
,2
]}

Park, Jae Yeong ^{[1
,2
,3
]}

机构：

[1] Kwangwoon Univ, Dept Elect Engn, Seoul 01897, South Korea

[2] Kwangwoon Univ, Adv Sensor & Energy Res ASER Lab, Seoul 01897, South Korea

[3] Kwangwoon Univ, Human IoT Focused Res Ctr, Seoul 01897, South Korea

来源：

ACS APPLIED MATERIALS & INTERFACES | 2024年 / 16卷 / 24期

关键词：

biofouling; functionalized 2D MXene; porousnanocomposite; electrochemical immunosensor; C-reactiveprotein and ferritin; ADSORPTION; PROTEIN; SURFACES; COATINGS; PLATFORM; CARBIDE; ALBUMIN;

D O I：

10.1021/acsami.4c05685

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Affinity-based electrochemical (AEC) biosensors have gained more attention in the field of point-of-care management. However, AEC sensing is hampered by biofouling of the electrode surface and degradation of the antifouling material. Therefore, a breakthrough in antifouling nanomaterials is crucial for the fabrication of reliable AEC biosensors. Herein, for the first time, we propose 1-pyrenebutyric acid-functionalized MXene to develop an antifouling nanocomposite to resist biofouling in the immunosensors. The nanocomposite consisted of a 3D porous network of bovine serum albumin cross-linked with glutaraldehyde with functionalized MXene as conductive nanofillers, where the inherited oxidation resistance property of functionalized MXene improved the electrochemical lifetime of the nanocomposite. On the other hand, the size-extruded porous structure of the nanocomposite inhibited the biofouling activity on the electrode surface for up to 90 days in real samples. As a proof of concept, the antifouling nanocomposite was utilized to fabricate a multiplexed immunosensor for the detection of C-reactive protein (CRP) and ferritin biomarkers. The fabricated sensor showed good selectivity over time and an excellent limit of detection for CRP and ferritin of 6.2 and 4.2 pg/mL, respectively. This research successfully demonstrated that functionalized MXene-based antifouling nanocomposites have great potential to develop high-performance and low-cost immunosensors.

引用

页码：31610 / 31623

页数：14