Annulation Reactions of Isoquinolinium Ylides with Sulfamate-Derived Cyclic Imines toward Polycyclic 1,3-Benzoxazepine Heterocycles

被引：1

作者：

Patra, Koushik ^{[1
]}

Mulani, Sana ^{[1
]}

Baidya, Mahiuddin ^{[1
]}

机构：

[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, India

来源：

SYNTHESIS-STUTTGART | 2025年 / 57卷 / 01期

关键词：

cascade annulation; dearomatization; benzoxazepines; (3+2) cycloaddition; heterocycles; ALDOL REACTION; N-SULFIMINES; DERIVATIVES; CASCADE; CYCLOADDITION; AMOXAPINE;

D O I：

10.1055/a-2349-6944

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A dearomatization-guided and (3+2) cycloaddition-triggered annulation reaction of in situ formed isoquinolinium ylides with sulfamate-derived cyclic imines is reported, offering a cogent synthesis of tetracyclic 1,3-benzoxazepine frameworks in high yields. The protocol features successive ring-forming and ring-breaking events in a cascade fashion and is also scalable.

引用

页码：109 / 114

页数：6

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