Synthesis, biocompatibility and biological activity of a graphene oxide-folic acid conjugate for cytarabine delivery

被引：3

作者：

Ageev, Sergei V. ^{[1
,2
]}

Semenov, Konstantin N. ^{[1
,2
,3
,4
]}

Shemchuk, Olga S. ^{[1
]}

Iurev, Gleb O. ^{[1
]}

Andoskin, Pavel A. ^{[1
]}

Rumiantsev, Andrei M. ^{[2
]}

Sambuk, Elena V. ^{[2
]}

Kozhukhov, Pavel K. ^{[1
]}

Maistrenko, Dmitrii N. ^{[3
]}

Molchanov, Oleg E. ^{[3
]}

Murin, Igor V. ^{[1
,2
]}

Mazur, Anton S. ^{[1
,2
]}

Sharoyko, Vladimir V. ^{[1
,2
,3
,4
]}

机构：

[1] Pavlov First St Petersburg State Med Univ, 6-8 Lva Tolstogo St, St Petersburg 197022, Russia

[2] St Petersburg State Univ, 7-9 Univ Skaia Embankment, St Petersburg 199034, Russia

[3] AM Granov Russian Res Ctr Radiol & Surg Technol, 70 Leningradskaia St, St Petersburg 197758, Russia

[4] 6-8 Lva Tolstogo Str, St Petersburg 197022, Russia

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2024年 / 697卷

关键词：

Graphene oxide; Folic acid; Cytarabine; Biocompatibility; Cytotoxicity; MECHANICAL-PROPERTIES; NANOMATERIALS; ADSORPTION; NANOCOMPOSITES; EXFOLIATION; CHEMISTRY; PROGRESS; DNA;

D O I：

10.1016/j.colsurfa.2024.134360

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The article is devoted to synthesis, characterisation and complex investigation of biocompatibility and cytotoxicity of graphene oxide conjugate with folic acid and cytarabine cytostatic (GO-FA-Cyt). GO was synthesised using a patented modified Hummers and Offeman's method leading to the production of GO enriched with oxygen-containing functional groups (similar to 85%). Obtained nanomaterial was covalently modified with FA and noncovalently functionalised with Cyt and characterised using C-13 NMR, Raman, and IR spectroscopy, XRD and DLS for aqueous dispersions. Biocompatibility and biological activity studies included investigation of haemocompatibility, antioxidant activity, genotoxicity, and cytotoxicity towards Jurkat, HL60 cell lines. The kinetic dependence of the adsorption of Cyt on the covalent GO-FA conjugate was obtained and described using various models: Brunauer, Emmett and Teller, Langmuir. Experimental data on release were fitted using zero-order, firstorder and Korsmeyer-Peppas models.

引用

页数：10

共 64 条

[1] Functionalisation of graphene as a tool for developing nanomaterials with predefined properties [J].

Abdelhalim, Abdelsattar O. E. ;

Semenov, Konstantin N. ;

Nerukh, Dmitry A. ;

V. Murin, Igor ;

Maistrenko, Dmitrii N. ;

Molchanov, Oleg E. ;

V. Sharoyko, Vladimir .

JOURNAL OF MOLECULAR LIQUIDS, 2022, 348

[2] Graphene oxide enriched with oxygen-containing groups: on the way to an increase of antioxidant activity and biocompatibility [J].

Abdelhalim, Abdelsattar O. E. ;

Meshcheriakov, Anatolii A. ;

Maistrenko, Dmitrii N. ;

Molchanov, Oleg E. ;

Ageev, Sergei, V ;

Ivanova, Daria A. ;

Iamalova, Nailia R. ;

Luttsev, Mikhail D. ;

Vasina, Lubov V. ;

Sharoyko, Vladimir V. ;

Semenov, Konstantin N. .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2022, 210

[3] Graphene Oxide of Extra High Oxidation: A Wafer for Loading Guest Molecules [J].

Abdelhalim, Abdelsattar O. E. ;

Sharoyko, Vladimir V. ;

Ageev, Sergei, V ;

Farafonov, Vladimir S. ;

Nerukh, Dmitry A. ;

Postnov, Viktor N. ;

Petrov, Andrey, V ;

Semenov, Konstantin N. .

JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2021, 12 (41) :10015-10024

[4] Reduction and functionalization of graphene oxide with L-cysteine: Synthesis, characterization and biocompatibility [J].

Abdelhalim, Abdelsattar O. E. ;

Sharoyko, Vladimir V. ;

Meshcheriakov, Anatolii A. ;

Martynova, Sofia D. ;

Ageev, Sergei, V ;

Iurev, Gleb O. ;

Al Mulla, Hadeer ;

Petrov, Andrey, V ;

Solovtsova, Irina L. ;

Vasina, Lubov V. ;

Murin, Igor, V ;

Semenov, Konstantin N. .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 29

[5] Synthesis, characterisation and biocompatibility of graphene-L-methionine nanomaterial [J].

Abdelhalim, Abdelsattar O. E. ;

Sharoyko, Vladimir V. ;

Meshcheriakov, Anatolii A. ;

Luttsev, Michail D. ;

Potanin, Artem A. ;

Iamalova, Nailia R. ;

Zakharov, Egor E. ;

Ageev, Sergei, V ;

Petrov, Andrey, V ;

Vasina, Lubov V. ;

Solovtsova, Irina L. ;

Nashchekin, Alexei, V ;

Murin, Igor, V ;

Semenov, Konstantin N. .

JOURNAL OF MOLECULAR LIQUIDS, 2020, 314

[6] Hybrid nanocomposite curcumin-capped gold nanoparticle-reduced graphene oxide: Antioxidant potency and selective cancer cytotoxicity [J].

Al-Ani, Lina A. ;

Yehyei, Wageeh A. ;

Kadir, Farkaad A. ;

Hashim, Najihah M. ;

AlSaadi, Mohammed A. ;

Julkapli, Nurhidayatullaili M. ;

Hsiao, Vincent K. S. .

PLOS ONE, 2019, 14 (05)

[7]

Alam S, 2017, 2017 INTERNATIONAL CONFERENCE ON BROADBAND COMMUNICATION, WIRELESS SENSORS AND POWERING (BCWSP), P1

[8] Graphene-Based Nanocomposites for Neural Tissue Engineering [J].

Bei, Ho Pan ;

Yang, Yuhe ;

Zhang, Qiang ;

Tian, Yu ;

Luo, Xiaoming ;

Yang, Mo ;

Zhao, Xin .

MOLECULES, 2019, 24 (04)

[9] A general strategy for direct synthesis of reduced graphene oxide by chemical exfoliation of graphite [J].

Betancur, A. F. ;

Ornelas-Soto, N. ;

Garay-Tapia, A. M. ;

Perez, F. R. ;

Salazar, Angel ;

Garcia, A. G. .

MATERIALS CHEMISTRY AND PHYSICS, 2018, 218 :51-61

[10] Adsorption of gases in multimolecular layers [J].

Brunauer, S ;

Emmett, PH ;

Teller, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1938, 60 :309-319

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