Metastatic triple-negative breast carcinoma mimicking melanoma: A potential diagnostic pitfall

被引:0
|
作者
Fliorent, Rebecca [1 ]
Benedetto, Conrad [2 ]
Theroux, Zachary [3 ]
机构
[1] Rowan Univ, Sch Osteopath Med, Stratford, NJ USA
[2] Burke Dermatol, Newark, DE USA
[3] Dermpath Diagnost, 3805 West Chester Pike Bldg D,Suite 120, Newtown Sq, PA 19073 USA
关键词
metastatic breast cancer; mimic; pitfall; PRAME; TNBC; IMMUNOHISTOCHEMISTRY UTILIZATION; PRAME; EXPRESSION; SOX10;
D O I
10.1111/cup.14658
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Melanoma, with its diverse histopathologic characteristics, can mimic both benign nevi and neoplasms of various cell lineages. Immunohistochemistry (IHC) can play a vital role in melanoma diagnosis, particularly when the cell lineage is unclear on hematoxylin and eosin sections. Commonly utilized IHC stains for melanoma diagnosis include SOX10, Melan-A, and S100. A relatively novel stain, PReferentially expressed Antigen in MElanoma (PRAME), is also proving useful in accurate melanoma diagnosis. However, none of these stains are completely specific to melanocytes or melanoma, and misinterpretation can lead to incorrect diagnoses. This report presents a unique case of triple-negative breast carcinoma (TNBC) metastatic to the skin exhibiting histopathologic characteristics similar to melanoma, including positivity for SOX10 and PRAME. Our aim is to highlight TNBC metastatic to the skin as a potential diagnostic pitfall.
引用
收藏
页码:654 / 657
页数:4
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