Metastatic triple-negative breast carcinoma mimicking melanoma: A potential diagnostic pitfall

被引:0
|
作者
Fliorent, Rebecca [1 ]
Benedetto, Conrad [2 ]
Theroux, Zachary [3 ]
机构
[1] Rowan Univ, Sch Osteopath Med, Stratford, NJ USA
[2] Burke Dermatol, Newark, DE USA
[3] Dermpath Diagnost, 3805 West Chester Pike Bldg D,Suite 120, Newtown Sq, PA 19073 USA
关键词
metastatic breast cancer; mimic; pitfall; PRAME; TNBC; IMMUNOHISTOCHEMISTRY UTILIZATION; PRAME; EXPRESSION; SOX10;
D O I
10.1111/cup.14658
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Melanoma, with its diverse histopathologic characteristics, can mimic both benign nevi and neoplasms of various cell lineages. Immunohistochemistry (IHC) can play a vital role in melanoma diagnosis, particularly when the cell lineage is unclear on hematoxylin and eosin sections. Commonly utilized IHC stains for melanoma diagnosis include SOX10, Melan-A, and S100. A relatively novel stain, PReferentially expressed Antigen in MElanoma (PRAME), is also proving useful in accurate melanoma diagnosis. However, none of these stains are completely specific to melanocytes or melanoma, and misinterpretation can lead to incorrect diagnoses. This report presents a unique case of triple-negative breast carcinoma (TNBC) metastatic to the skin exhibiting histopathologic characteristics similar to melanoma, including positivity for SOX10 and PRAME. Our aim is to highlight TNBC metastatic to the skin as a potential diagnostic pitfall.
引用
收藏
页码:654 / 657
页数:4
相关论文
共 50 条
  • [1] Metastatic Undifferentiated Melanoma Mimicking a Primary Bone Tumor: A Potential Diagnostic Pitfall
    Wills, Abby
    Dibbern, Megan
    Frierson, Henry F.
    Raghavan, Shyam S.
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2024, 46 (03) : 170 - 172
  • [2] Metastatic Triple-negative Breast Cancer
    Rakha, E. A.
    Chan, S.
    CLINICAL ONCOLOGY, 2011, 23 (09) : 587 - 600
  • [3] Metastatic Triple-Negative Breast Cancer
    Zhang, Xiaojie
    Yeung, Kay T.
    CURRENT BREAST CANCER REPORTS, 2023, 15 (03) : 288 - 297
  • [4] Metastatic Triple-Negative Breast Cancer
    Xiaojie Zhang
    Kay T. Yeung
    Current Breast Cancer Reports, 2023, 15 : 288 - 297
  • [5] Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma
    Sflomos, George
    Schaumann, Nora
    Christgen, Matthias
    Christgen, Henriette
    Bartels, Stephan
    Kreipe, Hans
    Battista, Laura
    Brisken, Cathrin
    CANCERS, 2023, 15 (13)
  • [6] Potential Role of miRNA in Metastatic Cascade of Triple-Negative Breast Cancer
    Balkrishna, Acharya
    Mittal, Rashmi
    Arya, Vedpriya
    CURRENT CANCER DRUG TARGETS, 2021, 21 (02) : 153 - 162
  • [7] MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer
    Iida, Mari
    Crossman, Bridget E.
    Kostecki, Kourtney L.
    Glitchev, Christine E.
    Kranjac, Carlene A.
    Crow, Madisen T.
    Adams, Jillian M.
    Liu, Peng
    Ong, Irene
    Yang, David T.
    Kang, Irene
    Salgia, Ravi
    Wheeler, Deric L.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (10)
  • [8] An unusual triple-negative breast carcinoma
    Shousha, Sami
    Peston, David
    Gojis, Ondrej
    Palmieri, Carlo
    HISTOPATHOLOGY, 2009, 55 (03) : 364 - 366
  • [9] Comparison of PELP1 and GATA3 Expression in Triple-Negative Breast Carcinoma: Potential Diagnostic Utility in Metastatic Disease
    Dang, D. N.
    Raj, G.
    Sarode, V.
    Vadlamudi, R. K.
    Peng, Y.
    LABORATORY INVESTIGATION, 2014, 94 : 43A - 43A
  • [10] Comparison of PELP1 and GATA3 Expression in Triple-Negative Breast Carcinoma: Potential Diagnostic Utility in Metastatic Disease
    Dang, D. N.
    Raj, G.
    Sarode, V.
    Vadlamudi, R. K.
    Peng, Y.
    MODERN PATHOLOGY, 2014, 27 : 43A - 43A