The chemistry and biological potential of azetidin-2-ones

被引：93
|
作者：
Arya, Nikhilesh [1 ,2 ]
Jagdale, Archana Y. [2 ]
Patil, Tushar A. [2 ]
Yeramwar, Shradha S. [2 ]
Holikatti, Sidharam S. [2 ]
Dwivedi, Jaya [1 ]
Shishoo, Chamanlal J. [3 ]
Jain, Kishor S. [2 ]
机构：
[1] Banasthali Univ, Dept Chem, Tonk 304022, Rajasthan, India
[2] Sinhgad Inst Pharmaceut Sci, Dept Pharmaceut Chem, Off Mumbai, Pune 410401, Maharashtra, India
[3] BV Patel Pharmaceut Educ & Res Dev PERD, Ahmadabad 380054, Gujarat, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 74卷
关键词：
Azetidin-2-ones; beta-Lactam; Synthesis; Pharmacological profile; HUMAN-LEUKOCYTE ELASTASE; BETA-LACTAM INHIBITORS; CHOLESTEROL ABSORPTION INHIBITORS; HUMAN CYTOMEGALOVIRUS PROTEASE; MICROWAVE-ASSISTED SYNTHESIS; MECHANISM-BASED INHIBITORS; ANTIMICROBIAL ACTIVITY; CATHEPSIN-K; 2-AZETIDINONE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS;
D O I：
10.1016/j.ejmech.2014.01.002
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Azetidin-2-ones, commonly referred as beta-lactams, represent a unique ring system, with interesting chemistry and great biological potential. Besides its well known antibiotic activity, this ring system exhibits a wide range of activities, attracting the attention of researchers. The biological and pharmacological profile of azetidin-2-ones is reviewed here comprehensively with several examples under fourteen different activity heads. The chemistry and methods of synthesis have also been discussed. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：619 / 656
页数：38
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