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Real-world effectiveness of long-acting injectable vs. oral antipsychotics in patients with bipolar I disorder: a 1-year retrospective observational study
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作者:

Korkmaz, Sukru Alperen
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h-index: 0
机构:
Canakkale Onsekiz Mart Univ, Dept Psychiat, Canakkale, Turkiye
Canakkale Onsekiz Mart Univ, Dept Psychiat, Canakkale Merkez, Turkiye Canakkale Onsekiz Mart Univ, Dept Psychiat, Canakkale, Turkiye

Gurler, Sumeyye
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h-index: 0
机构:
Ankara Bilkent City Hosp, Dept Neurol, Ankara, Turkiye Canakkale Onsekiz Mart Univ, Dept Psychiat, Canakkale, Turkiye
机构:
[1] Canakkale Onsekiz Mart Univ, Dept Psychiat, Canakkale, Turkiye
[2] Ankara Bilkent City Hosp, Dept Neurol, Ankara, Turkiye
[3] Canakkale Onsekiz Mart Univ, Dept Psychiat, Canakkale Merkez, Turkiye
关键词:
Antipsychotic depots;
antipsychotic long-acting injection;
bipolar disorder;
maintenance treatment;
relapse;
rehospitalization;
MAINTENANCE TREATMENT;
PHARMACOLOGICAL-TREATMENTS;
DOUBLE-BLIND;
RISPERIDONE;
LITHIUM;
MEDICATION;
PREVENTION;
EFFICACY;
COHORT;
D O I:
10.1080/03007995.2024.2337685
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
ObjectiveLong-acting injectable (LAI) antipsychotics are recommended in the treatment non-adherence. Despite the widespread use of LAI antipsychotics, there is limited data on clinical outcomes in bipolar I disorder (BD-I) patients with real-world data. We aimed to compare BD-I patients treated with LAI and oral antipsychotics (OAP) in terms of treatment effectiveness in a 1-year follow-up period.MethodsThe study was conducted retrospectively with electronic health records of 116 BDI patients. The primary outcomes were whether patients in the LAI group and the OAP group differed in relapse, rehospitalization, emergency room (ER) visits, and all-cause treatment discontinuation at 1-year follow-up after a mania episode. Cox regression modeling was used to predict the recurrence of any mood episode and all-cause treatment discontinuation during follow-up. The secondary outcomes evaluated were the effects of sociodemographic and clinical parameters and concomitant psychotropic medications on the course of the illness and treatment adherence.ResultsOf all 116 patients, 33 (28.4%) were under LAI, and 83 (71.6%) were under OAP treatment. LAI users had a history of more hospitalizations and total mood episodes. Patients in the LAI group had more treatment non-adherence before the index hospitalization. At 1-year follow-up, there was no difference between the groups in terms of any mood relapse, rehospitalization, ER visits, and all-cause treatment discontinuation. As a secondary outcome, lithium users were found to have fewer new episodes and discontinuations of treatments.ConclusionsIn real-world data, there is no evidence that LAI antipsychotics (compared to OAP) are superior in the maintenance treatment of BD. These results are important in terms of reflecting clinical practices for the treatment of BD-I. These results do not devalue the use of LAI therapy in BD; however, more studies are needed to identify positive predictors for LAI treatments in BD.
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页码:855 / 861
页数:7
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