Metabolomic pathways in food allergy

被引：7

作者：

Lee, So-Yeon ^{[1
]}

Park, Yoon Mee ^{[2
]}

Yoo, Hyun Ju ^{[3
]}

Hong, Soo-Jong ^{[4
]}

机构：

[1] PHI Digital Healthcare, Seoul, South Korea

[2] Univ Ulsan, Coll Med, Asan Inst Life Sci, Seoul, South Korea

[3] Univ Ulsan, Asan Inst Life Sci, Asan Med Ctr, Dept Convergence Med,Coll Med, Seoul, South Korea

[4] Univ Ulsan, Childhood Resp Allergy Ctr, Humidifier Disinfectant Hlth Ctr, Asan Med Ctr,Coll Med,Dept Pediat, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2024年 / 35卷 / 05期

关键词：

children; food allergy; metabolomics; URIC-ACID; TRYPTOPHAN-METABOLISM; BACTERIAL METABOLITES; BARRIER FUNCTION; SPHINGOLIPIDS; PROTECT; EPIDEMIOLOGY; INFLAMMATION; MICROBIOTA; DIAGNOSIS;

D O I：

10.1111/pai.14133

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Food allergy (FA) is a widespread issue, affecting as many as 10% of the population. Over the past two to three decades, the prevalence of FA has been on the rise, particularly in industrialized and westernized countries. FA is a complex, multifactorial disease mediated by type 2 immune responses and involving environmental and genetic factors. However, the precise mechanisms remain inadequately understood. Metabolomics has the potential to identify disease endotypes, which could beneficially promote personalized prevention and treatment. A metabolome approach would facilitate the identification of surrogate metabolite markers reflecting the disease activity and prognosis. Here, we present a literature overview of recent metabolomic studies conducted on children with FA. image image

引用

页数：11