Skin score correlates with global DNA methylation and GSTO1 A140D polymorphism in arsenic-affected population of Eastern India

被引：2
作者：
Majumder, Moumita [1 ]
Dasgupta, Uma B. [2 ]
Guha Mazumder, D. N. [3 ]
Das, Nilansu [1 ]
机构：
[1] Surendranath Coll, Dept Mol Biol, 24-2 Mahatma Gandhi Rd, Kolkata 700009, India
[2] Jadavpur Univ, Dept Life Sci & Biotechnol, Kolkata, India
[3] DNGM Res Fdn, Kolkata, India
来源：
TOXICOLOGY MECHANISMS AND METHODS | 2017年 / 27卷 / 06期
关键词：
Arsenic; whole genome DNA methylation; skin manifestation score; GSTO1*A140D; West Bengal; India; GLUTATHIONE-S-TRANSFERASE; DRINKING-WATER; LEUKOCYTE DNA; WEST-BENGAL; GENE P53; AS3MT; EXPOSURE; CELLS; METHYLTRANSFERASE; HYPOMETHYLATION;
D O I：
10.1080/15376516.2017.1323255
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Arsenic is a potent environmental toxicant causing serious public health concerns in India, Bangladesh and other parts of the world. Gene- and promoter-specific hypermethylation has been reported in different arsenic-exposed cell lines, whereas whole genome DNA methylation study suggested genomic hypo- and hypermethylation after arsenic exposure in in vitro and in vivo studies. Along with other characteristic biomarkers, arsenic toxicity leads to typical skin lesions. The present study demonstrates significant correlation between severities of skin manifestations with their whole genome DNA methylation status as well as with a particular polymorphism (Ala 140 Asp) status in arsenic metabolizing enzyme Glutathione S-transferase Omega-1 (GSTO1) in arsenic-exposed population of the district of Nadia, West Bengal, India.
引用
收藏
页码：467 / 475
页数：9
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