Serum copper and obesity among healthy adults in the National Health and Nutrition Examination Survey

被引:0
作者
Liu, Menglu [1 ]
Fang, Changchang [2 ]
Mei, Kaibo [3 ]
Ling, Jitao [2 ,4 ]
Fu, Wanying [2 ]
Qi, Xinrui [2 ]
Yu, Peng [2 ,4 ]
Yan, Zhiwei [5 ]
Xu, Liang [1 ]
Zhao, Yujie [1 ]
Li, Xiaozhong [6 ]
Liu, Xiao [7 ,8 ]
机构
[1] Seventh Peoples Hosp Zhengzhou, Dept Cardiol, Henan Prov Key Lab Arrhythmia, Henan Key Lab Cardiac Remodeling & Transplantat, Zhengzhou, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 2, Dept Endocrinol Med, Nanchang, Jiangxi, Peoples R China
[3] Peoples Hosp Shangrao, Dept Anesthesiol, Shangrao, Jiangxi, Peoples R China
[4] Inst Study Endocrinol & Metab Jiangxi, Nanchang, Jiangxi, Peoples R China
[5] Shenyang Sport Univ, Coll Kinesiol, Shenyang, Liaoning, Peoples R China
[6] Nanchang Univ, Affiliated Hosp 2, Dept Cardiol, Nanchang, Jiangxi, Peoples R China
[7] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou, Guangdong, Peoples R China
[8] Guangzhou Key Lab Mol Mech & Translat Major Cardio, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangdong Hong Kong Joint Lab RNA Med, Guangzhou, Guangdong, Peoples R China
来源
PLOS ONE | 2024年 / 19卷 / 06期
关键词
OXIDATIVE STRESS; ASSOCIATION; OVERWEIGHT; MORTALITY; INSULIN;
D O I
10.1371/journal.pone.0300795
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Copper (Cu) homeostasis are important processes in the cause of metabolic diseases, but the association between Cu and obesity remains unclear.Methods Participants were drawn from the 2011-2016 National Health and Nutrition Examination Survey (NHANES). Weighted logistic regression assessed the associations of serum Cu concentrations (tertiles) with obesity and central obesity in individuals without comorbidities. Obesity was defined as a BMI >= 30.0 kg/m2, and central obesity was defined as a waist circumference >= 80 cm for women and >= 95 cm for men.Results This cross-sectional study included 1,665 adults without comorbidities, representing 24,744,034 people (mean age 35.1 years, 48.5% female). High serum Cu levels (tertile 3: >= 19.19 mu mol/L) were associated with higher odds of obesity (adjusted odds ratio [OR]: 4.48, 95% CI[confidence interval]: 2.44-8.32) and central obesity (OR: 2.36, 95% CI: 1.19-4.66) compared to low serum Cu levels (tertile 1: <= 15.64 mu mol/L). The dose-response curve showed a nonlinear association between Cu levels and obesity (P-nonlinear = 0.02) and a linear association with central obesity (P-nonlinear = 0.21).Conclusion This study suggests that higher serum Cu levels are associated with increased odds of obesity in healthy American adults.
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页数:14
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