Sex and gender in alcohol use disorder and alcohol-associated liver disease in the United States: A narrative review

被引:3
作者
Carlini, Lauren E. [1 ]
Fernandez, Anne C. [2 ]
Mellinger, Jessica L. [3 ]
机构
[1] Univ Kansas, Med Ctr, Dept Internal Med, Kansas City, KS USA
[2] Michigan Med, Dept Psychiat, Ann Arbor, MI USA
[3] Michigan Med, Dept Internal Med & Psychiat, Ann Arbor, MI USA
关键词
NATIONAL EPIDEMIOLOGIC SURVEY; DEPRESSIVE SYMPTOMS; KUPFFER CELLS; WOMEN; RISK; DRINKING; WITHDRAWAL; DEPENDENCE; ESTROGEN; TRANSPLANTATION;
D O I
10.1097/HEP.0000000000000905
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Over the last 20 years, there has been an alarming increase in alcohol use and AUD prevalence among women, narrowing the historical gender gap. Concurrently, there has also been a significant rise in alcohol-associated liver disease (ALD) prevalence, severity, and mortality among women. Despite this, there are no recent reviews that have sought to evaluate both sex and gender differences at the intersection of AUD and ALD. In this narrative review, we address the escalating rates of ALD and AUD in the United States, with a specific focus on the disproportionate impact on women. Sex and gender play an important and well-known role in the pathogenesis and epidemiology of ALD. However, sex and gender are also implicated in the development and prevalence of AUD, as well as in the treatment of AUD, all of which have important consequences on the approach to the treatment of patients with ALD and AUD. A better understanding of sex and gender differences in AUD, ALD, and the intersection of the 2 is essential to enhance prevention, diagnosis, and management strategies. These data underscore the urgent need for awareness and preventive efforts to mitigate the potential long-term health consequences.
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页数:17
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