Candida albicans increases the aerobic glycolysis and activates MAPK- dependent in fl ammatory response of liver sinusoidal endothelial cells

被引：3

作者：

Aparicio-Fernandez, Leire ^{[1
]}

Antoran, Aitziber ^{[1
]}

Areitio, Maialen ^{[1
]}

Rodriguez-Erenaga, Oier ^{[1
]}

Martin-Souto, Leire ^{[1
]}

Buldain, Idoia ^{[2
]}

Marquez, Joana ^{[3
]}

Benedicto, Aitor ^{[3
,4
]}

Arteta, Beatriz ^{[3
,4
]}

Pellon, Aize ^{[5
]}

Moyes, David L. ^{[5
]}

Rementeria, Aitor ^{[1
]}

-Garcia, Andoni Ramirez ^{[1
]}

机构：

[1] Univ Basque Country UPV EHU, Fac Sci & Technol, Dept Immunol Microbiol & Parasitol, Barrio Sarriena W-O, Leioa 48940, Spain

[2] Univ Basque Country UPV EHU, Fac Pharm, Dept Immunol Microbiol & Parasitol, Vitoria 01006, Spain

[3] Univ Basque Country UPV EHU, Cell Biol & Histol Dept, Leioa 48940, Spain

[4] Univ Basque Country UPV EHU, Canc & Translat Med Res Grp, Leioa 48940, Spain

[5] Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 1UL, England

来源：

MICROBES AND INFECTION | 2024年 / 26卷 / 04期

关键词：

Liver endothelium; Candida; In flammation; Metabolism; Immune response; Aerobic glycolysis; EXPRESSION; MECHANISMS; TRIGGERS; YEAST;

D O I：

10.1016/j.micinf.2024.105305

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The liver, and more specifically, the liver sinusoidal endothelial cells, constitute the beginning of one of the most important responses for the elimination of hematogenously disseminated Candida albicans. Therefore, we aimed to study the mechanisms involved in the interaction between these cells and C. albicans. Transcriptomics-based analysis showed an increase in the expression of genes related to the immune response (including receptors, cytokines, and adhesion molecules), as well as to aerobic glycolysis. Further in vitro analyses showed that IL-6 production in response to C. albicans is controlled by MyD88- and SYK-pathways, suggesting an involvement of Toll-like and C-type lectin receptors and the subsequent activation of the MAP-kinases and c-Fos/AP-1 transcription factor. In addition, liver sinusoidal endothelial cells undergo metabolic reprogramming towards aerobic glycolysis induced by C. albicans, as confirmed by the increased Extracellular Acidification Rate and the overexpression of enolase (Eno2), hexonikase (Hk2) and glucose transporter 1 (Slc2a1). In conclusion, these results indicate that the hepatic endothelium responds to C. albicans by increasing aerobic glycolysis and promoting an inflammatory environment. (c) 2024 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：10

共 34 条

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