Connective Tissue Growth Factor: Regulation, Diseases, and Drug Discovery

被引：4

作者：

Ren, Meishen ^{[1
,2
]}

Yao, Shanshan ^{[3
]}

Chen, Tienan ^{[2
]}

Luo, Hang ^{[3
]}

Tao, Xiaohui ^{[2
]}

Jiang, Hewen ^{[3
]}

Yang, Xin ^{[2
]}

Zhang, Huarui ^{[3
]}

Yu, Sifan ^{[3
]}

Wang, Yin ^{[1
]}

Lu, Aiping ^{[2
]}

Zhang, Ge ^{[2
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Peoples R China

[2] Hong Kong Baptist Univ, Law Sau Fai Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Fac Med, Sch Chinese Med, Shatin, Hong Kong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 09期

关键词：

CTGF/CCN2; regulation mechanism; therapeutic target; drug discovery; CTGF-related diseases; PULMONARY-FIBROSIS; CLINICAL-TRIAL; CELL THERAPY; FACTOR BINDS; CTGF; LATANOPROST; COMBINATION; FIBRONECTIN; MECHANISMS; FIBROBLAST;

D O I：

10.3390/ijms25094692

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In drug discovery, selecting targeted molecules is crucial as the target could directly affect drug efficacy and the treatment outcomes. As a member of the CCN family, CTGF (also known as CCN2) is an essential regulator in the progression of various diseases, including fibrosis, cancer, neurological disorders, and eye diseases. Understanding the regulatory mechanisms of CTGF in different diseases may contribute to the discovery of novel drug candidates. Summarizing the CTGF-targeting and -inhibitory drugs is also beneficial for the analysis of the efficacy, applications, and limitations of these drugs in different disease models. Therefore, we reviewed the CTGF structure, the regulatory mechanisms in various diseases, and drug development in order to provide more references for future drug discovery.

引用

页数：23

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