Asymmetric Total Synthesis of Lobophopyranone A and B

被引：0

作者：

Reddy, G. Sudhakar ^{[1
,2
]}

Choudhury, Utkal Mani ^{[1
,2
]}

Keerthana, H. Sai ^{[1
]}

Naik, K. Charan ^{[1
,2
]}

Mohapatra, Debendra K. ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

来源：

SYNTHESIS-STUTTGART | 2025年 / 57卷 / 01期

关键词：

lobophopyranone; natural products; asymmetric synthesis; Keck-Maruoka allylations; Sakurai allylation; acid-mediated cyclization; IODOXYBENZOIC ACID IBX; BIS(((S)-BINAPHTHOXY)(ISOPROPOXY)TITANIUM) OXIDE; LOBOPHORA-VARIEGATA; SECONDARY ALCOHOLS; ORGANIC-SYNTHESIS; CYCLIC PEROXIDES; ALLYLATION; OXIDATION; METABOLITES; CLEAVAGE;

D O I：

10.1055/a-2338-4462

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first asymmetric total synthesis and structural confirmation of lobophopyranone A and B have been accomplished from commercially available starting materials. Reagent-controlled Keck-Maruoka allylation, Grignard reaction, chelation-controlled Sakurai allylation, and acid-mediated one-step TBS ether deprotection followed by cyclization are the crucial stages in this synthesis that create the 2,6-disubstituted dihydropyranone component.

引用

页码：99 / 108

页数：10

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