Dysbiosis and Regulation of Gut Microbiota in Type 2 Diabetes Mellitus

被引:0
作者
Minakshi, Hemlata [1 ]
Kumari, Hemlata [1 ]
Prakash, Shaurya [1 ]
Kumar, Antresh [1 ]
机构
[1] Cent Univ Haryana, Dept Biochem, Mahendergarh 123029, Haryana, India
关键词
Diabetes; Gut microbiota; dysbiosis; Trimethylamine N-oxide; Short-chain fatty acids; endotoxemia; Aromatic amino acids; CHINESE POPULATION; RISK; DIET; OBESITY; SERUM;
D O I
10.2174/0113892010318580240910061534
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Type 2 diabetes mellitus is a serious metabolic disease having a high growth rate and becoming a global threat. An unhealthy lifestyle, food intake, and genetic susceptibility are the major factors responsible for this metabolic disorder. This disease results in hyperlipidemia, hyperglycemia, glucose intolerance, restricted insulin synthesis, and insulin resistance. Despite a variety of treatments currently available, cases of diabetes and resulting complications are on the rise. One promising approach to diabetes focuses on gut microflora and their associated metabolites. Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology. This study explores the dysbiosis in the human gut microflora in Type 2 Diabetes Mellitus and how the gut microbiota influences metabolites related to T2DM. It also sheds light on early identification and targeted intervention for this. Understanding these mechanisms could potentially lead to more effective strategies for managing and preventing T2DM. The findings of our literature study are that gut microbiota can serve as biomarkers for early disease detection. Finally, we also highlight gut microecological therapeutic strategies focused on shaping the gut flora to emphasize the improvement of T2DM progression.
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页数:22
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