Dnttip2 is essential for 18S rRNA processing and digestive organ development in zebrafish

被引：0

作者：

Zhou, Ru ^{[1
]}

Cui, Wei ^{[1
]}

Zeng, Ni ^{[1
]}

Su, Baochun ^{[1
]}

Chen, Yayue ^{[1
]}

Shi, Hui ^{[1
]}

Zhao, Shuyi ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2024年 / 709卷

基金：

中国国家自然科学基金;

关键词：

Dnttip2; Digestive organ development; Zebrafish; 18S rRNA processing; PRECURSOR; DEPLETION;

D O I：

10.1016/j.bbrc.2024.149838

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dnttip2 is one of the components of the small subunit (SSU) processome. In yeast, depletion of dnttip2 leads to an inefficient processing of pre-rRNA and a decrease in synthesis of the mature 18S rRNA. However, the biological roles of Dnttip2 in higher organisms are poorly defined. In this study, we demonstrate that dnttip2 is a maternal gene in zebrafish. Depletion of Dnttip2 leads to embryonic lethal with severe digestive organs hypoplasia. The loss of function of Dnttip2 also leads to partial defects in cleavage at the A 0 -site and E-site during 18S rRNA processing. In conclusion, Dnttip2 is essential for 18S rRNA processing and digestive organ development in zebrafish.

引用

页数：7

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