A Review of Immunotherapy in Non-Small-Cell Lung Cancer

被引：5

作者：

Capella, Mariana Pilon ^{[1
]}

Pang, Steph A. ^{[1
]}

Magalhaes, Marcos A. ^{[2
]}

Esfahani, Khashayar ^{[1
,3
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Dept Oncol, Montreal, PQ H3T 1E2, Canada

[2] Hosp Beneficencia Portuguesa Sao Paulo, Dept Oncol, BR-01451010 Sao Paulo, Brazil

[3] McGill Univ, St Marys Hosp, Dept Oncol, Montreal, PQ H3T 1M5, Canada

来源：

CURRENT ONCOLOGY | 2024年 / 31卷 / 06期

关键词：

immunotherapy; non-small-cell lung cancer; squamous cell lung cancer; PD-1; CTLA-4; SPECIFIED FINAL ANALYSIS; BRAIN METASTASES; PLUS CHEMOTHERAPY; ADVERSE EVENTS; OPEN-LABEL; PHASE-III; PD-1/PD-L1; INHIBITORS; CLINICAL-OUTCOMES; PEMBROLIZUMAB; NSCLC;

D O I：

10.3390/curroncol31060258

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer immunotherapy in the form of immune checkpoint inhibitors has led to a dramatic increase in the survival of patients with lung cancer across all stages. Over the past decade, the field has experienced rapid maturation; however, several challenges continue to complicate patient management. This review aims to highlight the data that led to this dramatic shift in practice as well as to focus on key challenges. These include determining the optimal therapy duration, managing frail patients or those with brain metastases, addressing the challenges posed by immune-related adverse events, and defining the various patterns of clinical and radiological responses to immunotherapy.

引用

页码：3495 / 3512

页数：18

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