ASME Case N-888, Similar and Dissimilar Metal Welding Using Ambient Temperature SMAW and Machine GTAW Temper Bead Technique, requires a 48-hour hold time before nondestructive examination (NDE) can be performed to ensure hydrogen-induced cracking (HIC) did not occur. The aim of this work is to assess and characterize the HIC susceptibility of SA-508 pressure vessel steel. The results from this study will be used to consider potential elimination of the NDE hold time requirement in Case N-888. The Gleeble (TM) thermo-mechanical simulator was used to recreate CGHAZ for five weld conditions; as-welded, post-weld heat treated (PWHT), and four single-reheat temperatures of 675 degrees C, 700 degrees C, 725 degrees C, and 735 degrees C to simulate temper bead welding (TBW). Metallurgical characterization revealed a tempered martensitic microstructure for all TBW and the PWHT conditions. The 735 degrees C TBW sample developed ferrite along the prior austenite grain boundaries. The single reheats to 675 degrees C, 700 degrees C and 735 degrees C reduced the as-welded CGHAZ hardness from 425HV(0.5) respectively to 313, 298, and 278HV(0.5). A fourth TBW condition was added at 725 degrees C to eliminate ferrite formation seen at 735 degrees C. The TBW at 725 degrees C produced a microstructure of tempered martensite with a hardness of 298HV(0.5). The HIC susceptibility is being evaluated using the Delayed Hydrogen Crack Test (DHCT) developed at the Ohio State University. Samples of SA-508 steel with the five CGHAZ microstructural conditions are loaded at 90% of the base metal yield strength and simultaneously electrolytically charged with hydrogen. The HIC susceptibility is ranked by the time to failure (full specimen separation) and sustained mechanical energy.