Hormone-binding proteins and their associated hormones in patients with nephrotic syndrome

Aim: In the current study, we aimed to evaluate SHBG and TBG levels and their related hormone levels in patients with nephrotic syndrome and the control group. Material and Methods: The current study was conducted at Istanbul University Cerrahpa & scedil;a Faculty of Medicine, Department of Internal Medicine, with a total of 33 patients and 11 healthy controls. The study groups were divided into 3 groups: normal serum creatine level, high serum creatine level and control group. SHBG, TBG, T3, T4, fT3, fT4, TSH, testosterone, free testosterone, prolactin, FSH, and LH levels were determined in all groups. Proteinuria, hypoalbuminemia, and hyperlipidemia were present in the patient groups. Results: The mean age was 31.0 +/- 11.0 years (Group 1), and 46 +/- 15 years (Group 2) in patients with nephrotic syndrome. In the control group, the mean age was 29.0 +/- 7.0 years. TBG, T3, T4, fT3, fT4 and TSH levels were found to be lower in the patient groups than in the control group. No statistically significant correlation was detected between SHBG and TGB and albumin, globulin and proteinuria, which are indicators of nephrotic syndrome. Discussion: Nephrotic syndrome has important effects on the metabolism and regulation of protein or protein-protein-bound hormones and prohormones. This study indicates that individuals with nephrotic syndrome experience notable changes in SHBG, TBG, and related hormones. It can be said that this situation occurs as a result of the loss of both hormones and the proteins that bind these hormones from the kidneys.