Remdesivir treatment does not reduce viral titers in patients with COVID-19

被引：4

作者：

Faghihi, Isa ^{[1
]}

Yan, Victoria C. ^{[1
]}

机构：

[1] Univ Texas Southwestern Med Ctr, Dallas, TX 75390 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2024年 / 68卷 / 08期

关键词：

remdesivir; SARS-CoV-2; COVID-19; pharmacology; pharmacodynamics; antivirals; drug development;

D O I：

10.1128/aac.00856-24

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The relationship (or lack thereof) between the clinical activity of remdesivir and its ability to reduce viral titers in patients with COVID-19 has not been fully delineated. There is a misconception that remdesivir was FDA-approved for COVID-19 due to its ability to reduce viral titers. Here, we analyze all clinical studies of remedesivir in COVID-19 that quantifed SARS-CoV-2 titers. As of 28 June 2024, we show there is no significant decrease in SARS-CoV-2 viral titers in patients treted with remdesivir compared to placebo controls.

引用

页数：4

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