Fusobacterium Detected in Barrett's Esophagus and Esophageal Adenocarcinoma Tissues

被引：0

作者：

Tahara, Tomomitsu ^{[1
]}

Shijimaya, Takuya ^{[1
]}

Yamazaki, Jumpei ^{[2
,3
]}

Kobayashi, Sanshiro ^{[1
]}

Horitani, Anna ^{[1
]}

Matsumoto, Yasushi ^{[1
]}

Nakamura, Naohiro ^{[1
]}

Okazaki, Takashi ^{[1
]}

Takahashi, Yu ^{[1
]}

Tomiyama, Takashi ^{[1
]}

Honzawa, Yusuke ^{[1
]}

Fukata, Norimasa ^{[1
]}

Fukui, Toshiro ^{[1
]}

Naganuma, Makoto ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Internal Med 3, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan

[2] Hokkaido Univ, Fac Vet Med, Vet Teaching Hosp, Translat Res Unit, Sapporo, Japan

[3] Hokkaido Univ, Hlth Res Ctr 1, Sapporo, Japan

来源：

CANCER INVESTIGATION | 2024年 / 42卷 / 06期

关键词：

Barrett's esophagus; esophageal adenocarcinoma; Fusobacterium species; Fusobacterium nucreatum; whole Fusobacterium species; DNA methylation; Short-segment Barrett's esophagus; Long-segment Barrett's esophagus; Japanese; Telomere shortening; HUMAN MICROBIOME; NUCLEATUM; CANCER;

D O I：

10.1080/07357907.2024.2359980

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined Fusobacterium nucreatum (F. nucleatum) and whole Fusobacterium species (Pan-fusobacterium) in non-neoplastic Barrett's esophagus (BE) from patients without cancer (n = 67; N group), with esophageal adenocarcinoma (EAC) (n = 27) and EAC tissue (n = 22). F. nucleatum was only detectable in 22.7% of EAC tissue. Pan-fusobacterium was enriched in EAC tissue and associated with aggressive clinicopathological features. Amount of Pan-fusobacterium in non-neoplastic BE was correlated with presence of hital hernia and telomere shortening. The result suggested potential association of Fusobacterium species in EAC and BE, featuring clinicpathological and molecular features.

引用

页码：469 / 477

页数：9

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