Epigenetics in Alzheimer's Disease: A Critical Overview

被引：6
作者：
Villa, Chiara [1 ]
Combi, Romina [1 ]
机构：
[1] Univ Milano Bicocca, Sch Med & Surg, I-20900 Monza, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 11期
关键词：
epigenetics; Alzheimer's disease; aging; DNA METHYLATION; MOUSE MODEL; COGNITIVE IMPAIRMENT; AGE; BIOMARKERS; GENES; BLOOD; ASSOCIATION; DIAGNOSIS; PROFILES;
D O I：
10.3390/ijms25115970
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epigenetic modifications have been implicated in a number of complex diseases as well as being a hallmark of organismal aging. Several reports have indicated an involvement of these changes in Alzheimer's disease (AD) risk and progression, most likely contributing to the dysregulation of AD-related gene expression measured by DNA methylation studies. Given that DNA methylation is tissue-specific and that AD is a brain disorder, the limitation of these studies is the ability to identify clinically useful biomarkers in a proxy tissue, reflective of the tissue of interest, that would be less invasive, more cost-effective, and easily obtainable. The age-related DNA methylation changes have also been used to develop different generations of epigenetic clocks devoted to measuring the aging in different tissues that sometimes suggests an age acceleration in AD patients. This review critically discusses epigenetic changes and aging measures as potential biomarkers for AD detection, prognosis, and progression. Given that epigenetic alterations are chemically reversible, treatments aiming at reversing these modifications will be also discussed as promising therapeutic strategies for AD.
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页数：14
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