Synthesis, Structure, and Antimicrobial Properties of New Cobalt(II) Complexes with 1-Propargylimidazoles

被引：1
作者：
Sterkhova, Irina V. [1 ]
Parshina, Lidiya N. [1 ]
Grishchenko, Lyudmila A. [1 ]
Borodina, Tatyana N. [1 ]
Belovezhets, Lyudmila A. [1 ]
Semenov, Valentin A. [1 ]
机构：
[1] Russian Acad Sci, AE Favorsky Irkutsk Inst Chem, Siberian Branch, 1 Favorsky St, Irkutsk 664033, Russia
来源：
CURRENT ORGANIC CHEMISTRY | 2024年 / 28卷 / 09期
基金：
俄罗斯科学基金会;
关键词：
1-Propargylimidazole; 1-propargyl-2-methylimidazole; 1-propargyl-2-benzimidazole; complexes of cobalt(II); X-ray analysis; AIM analysis; antimicrobial activity; METAL-COMPLEXES; CRYSTAL-STRUCTURE; CYTOTOXIC ACTIVITY; COORDINATION; IMIDAZOLE; LIGANDS; BONDS; ANTIBACTERIAL; COPPER(II); ZINC(II);
D O I：
10.2174/0113852728295396240314054651
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Complexes of cobalt(II) chloride with 1-propargylimidazole, 1-propargyl-2-methylimidazole, and 1-propargylbenzimidazole ligands were synthesized and studied by FTIR spectroscopy and X-ray analysis. According to the X-ray analysis, the crystal molecules of compounds were connected by non-covalent interactions, such as halogen bonds and pi-stacking. The nature and energy of coordination metal-ligand and non-covalent bonds for structures under study were estimated in the frame of QTAIM (Quantum Theory "Atoms In Molecules"). The antimicrobial activity of obtained cobalt(II) chloride complexes was evaluated in relation to microorganisms E. durans, B. subtilis, and E. coli. Complexes of 1-propargyl-2-methylimidazole and 1-propargylbenzimidazole with cobalt(II) chloride demonstrated high activity against E. coli and E. durans relatively and could be recommended as antimicrobial drugs.
引用
收藏
页码：708 / 715
页数：8
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