ABSORPTION AND DISTRIBUTION OF ULTRATRACE EXOGENOUS 14C UREA IN RATS

被引：0

作者：

Wang, Li ^{[1
,2
]}

Shen, Hongtao ^{[1
]}

Tang, Junsen ^{[1
]}

Zhang, Guofeng ^{[1
]}

Qi, Linjie ^{[1
]}

Chen, Dingxiong ^{[1
]}

Wu, Kaiyong ^{[1
]}

Han, Xinyi ^{[1
]}

Ouyang, He ^{[1
]}

He, Yun ^{[1
]}

Yang, Pucheng ^{[3
]}

Zhang, Xue ^{[3
]}

Xia, Chunbo ^{[3
]}

机构：

[1] Guangxi Normal Univ, Guangxi Key Lab Nucl Phys & Technol, Guilin 541004, Peoples R China

[2] Hubei Univ, Sch Phys, Wuhan 430062, Hubei, Peoples R China

[3] Guilin Med Univ, Guilin 541004, Peoples R China

来源：

RADIOCARBON | 2024年 / 66卷 / 05期

基金：

中国国家自然科学基金;

关键词：

accelerator mass spectrometry; C-14; urea; distribution; pharmacokinetics; ultratrace; ACCELERATOR MASS-SPECTROMETRY; C-14-LABELED UREA; METABOLISM; GRAPHITIZATION; DISPOSITION; REDUCTION; TARGETS; TISSUES; SAMPLES; ZINC;

D O I：

10.1017/RDC.2024.47

中图分类号：

P3 [地球物理学]; P59 [地球化学];

学科分类号：

0708 ; 070902 ;

摘要：

The absorption and distribution of radiocarbon-labeled urea at the ultratrace level were investigated with a C-14-AMS biotracer method. The radiopharmaceutical concentrations in the plasma, heart, liver, spleen, lung, kidney, stomach, brain, bladder, muscle, testis, and fat of rats after oral administration of C-14 urea at ultratrace doses were determined by AMS, and the concentration-time curves in plasma and tissues and pharmacokinetic distribution data were obtained. This study provides an analytical method for the pharmacokinetic parameters and tissue distribution of exogenous urea in rats at ultratrace doses and explores the feasibility of evaluation and long-term tracking of ultratrace doses of drugs with AMS.

引用

页码：1450 / 1459

页数：10

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