ABSORPTION AND DISTRIBUTION OF ULTRATRACE EXOGENOUS 14C UREA IN RATS

被引：0
|
作者：
Wang, Li [1 ,2 ]
Shen, Hongtao [1 ]
Tang, Junsen [1 ]
Zhang, Guofeng [1 ]
Qi, Linjie [1 ]
Chen, Dingxiong [1 ]
Wu, Kaiyong [1 ]
Han, Xinyi [1 ]
Ouyang, He [1 ]
He, Yun [1 ]
Yang, Pucheng [3 ]
Zhang, Xue [3 ]
Xia, Chunbo [3 ]
机构：
[1] Guangxi Normal Univ, Guangxi Key Lab Nucl Phys & Technol, Guilin 541004, Peoples R China
[2] Hubei Univ, Sch Phys, Wuhan 430062, Hubei, Peoples R China
[3] Guilin Med Univ, Guilin 541004, Peoples R China
来源：
RADIOCARBON | 2024年 / 66卷 / 05期
基金：
中国国家自然科学基金;
关键词：
accelerator mass spectrometry; C-14; urea; distribution; pharmacokinetics; ultratrace; ACCELERATOR MASS-SPECTROMETRY; C-14-LABELED UREA; METABOLISM; GRAPHITIZATION; DISPOSITION; REDUCTION; TARGETS; TISSUES; SAMPLES; ZINC;
D O I：
10.1017/RDC.2024.47
中图分类号：
P3 [地球物理学]; P59 [地球化学];
学科分类号：
0708 ; 070902 ;
摘要：
The absorption and distribution of radiocarbon-labeled urea at the ultratrace level were investigated with a C-14-AMS biotracer method. The radiopharmaceutical concentrations in the plasma, heart, liver, spleen, lung, kidney, stomach, brain, bladder, muscle, testis, and fat of rats after oral administration of C-14 urea at ultratrace doses were determined by AMS, and the concentration-time curves in plasma and tissues and pharmacokinetic distribution data were obtained. This study provides an analytical method for the pharmacokinetic parameters and tissue distribution of exogenous urea in rats at ultratrace doses and explores the feasibility of evaluation and long-term tracking of ultratrace doses of drugs with AMS.
引用
收藏
页码：1450 / 1459
页数：10
相关论文
共 50 条
  • [21] Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration
    Matthew Hoffmann
    Claudia Kasserra
    Josephine Reyes
    Peter Schafer
    Jolanta Kosek
    Lori Capone
    Anastasia Parton
    Heasook Kim-Kang
    Sekhar Surapaneni
    Gondi Kumar
    Cancer Chemotherapy and Pharmacology, 2013, 71 : 489 - 501
  • [22] ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF [C-14] EBASTINE AFTER A SINGLE ADMINISTRATION IN RATS
    FUJII, T
    MATSUMOTO, S
    AMEJIMA, H
    HATOYAMA, T
    NAKAO, M
    KAGEMOTO, A
    TANAKA, K
    MIYAZAKI, H
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1994, 44-1 (04): : 527 - 538
  • [23] Absorption, metabolism, excretion, and safety of [14C]almonertinib in healthy Chinese subjects
    Zhou, Chen
    Xie, Lijun
    Liu, Wei
    Zhang, Lingling
    Zhou, Sufeng
    Wang, Lu
    Chen, Juan
    Li, Huan
    Zhao, Yuqing
    Zhu, Bei
    Ding, Sijia
    Zhang, Chen
    Shao, Feng
    ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (10)
  • [24] Absorption, distribution, metabolism and excretion of 14C-vatiquinone in rats, dogs, and human subjects
    Ma, Jiyuan
    Lee, Lucy
    Yao, Bert
    Giannousis, Peter
    Thoolen, Martin
    Ye, Qing
    Golden, Lee
    Klein, Matthew
    Kong, Ronald
    XENOBIOTICA, 2023, 53 (05) : 396 - 411
  • [25] Disposition of exogenous urea and effects of diet in rats
    Nomura, N
    Matsumoto, S
    Nishimura, Y
    Terauchi, Y
    Fujii, T
    ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2006, 56 (03): : 258 - 266
  • [26] Disposition of sodium and potassium [14C]-benzoate (BA) orally administered to rats
    Kurebayashi, H
    Takahashi, T
    Kaniwa, N
    Takahashi, A
    JOURNAL OF HEALTH SCIENCE, 1999, 45 (06) : 391 - 400
  • [27] In Vivo Bioavailability, Absorption, Excretion, and Pharmacokinetics of [14C]Procyanidin B2 in Male Rats
    Stoupi, Stavroula
    Williamson, Gary
    Viton, Florian
    Barron, Denis
    King, Laurence J.
    Brown, Jonathan E.
    Clifford, Michael N.
    DRUG METABOLISM AND DISPOSITION, 2010, 38 (02) : 287 - 291
  • [28] Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [14C]aficamten following single oral dose administration to rats
    Grillo, Mark P.
    Sukhun, Rajaa
    Bashir, Mohammad
    Ashcraft, Luke
    Morgan, Bradley P.
    XENOBIOTICA, 2024, 54 (09) : 670 - 685
  • [29] Metabolism, pharmacokinetics and excretion of the GABAA receptor partial agonist [14C]CP-409,092 in rats
    Kamel, A.
    Obach, R. S.
    Tseng, E.
    Sawant, A.
    XENOBIOTICA, 2010, 40 (06) : 400 - 414
  • [30] The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [14C]Binimetinib 45 mg in Healthy Male Participants
    Huynh, Dustin
    Hahn, Erik
    Reddy, Micaela B.
    Chavira, Renae
    Wollenberg, Lance
    PHARMACOLOGY RESEARCH & PERSPECTIVES, 2025, 13 (01):
12345