Circadian and sleep phenotypes in a mouse model of Alzheimer's disease characterized by intracellular accumulation of amyloid β oligomers

被引：4

作者：

Sato, Tomoyuki ^{[1
]}

Ochiishi, Tomoyo ^{[2
]}

Higo-Yamamoto, Sayaka ^{[1
]}

Oishi, Katsutaka ^{[1
,3
,4
,5
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Cellular & Mol Biotechnol Res Inst, Hlth Food Sci Res Grp, Cent 6,1-1-1 Higashi, Tsukuba, Ibaraki 3058566, Japan

[2] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst BMRI, Mol Neurobiol Res Grp, Cent 6,1-1-1 Higashi, Tsukuba, Ibaraki 3058566, Japan

[3] Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, 5-1-5 Kashiwanoha, Kashiwa, Chiba 2770882, Japan

[4] Tokyo Univ Sci, Grad Sch Sci & Technol, Dept Appl Biol Sci, 2641 Yamazaki, Noda, Chiba 2788510, Japan

[5] Univ Tsukuba, Sch Integrat & Global Majors, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058577, Japan

来源：

EXPERIMENTAL ANIMALS | 2024年 / 73卷 / 02期

基金：

日本学术振兴会;

关键词：

Alzheimer's disease; amyloid beta; circadian rhythm; sleep; MILD COGNITIVE IMPAIRMENT; MEMORY; PLAQUES; BRAIN;

D O I：

10.1538/expanim.23-0104

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Disturbances in sleep-wake and circadian rhythms may reportedly precede the onset of cognitive symptoms in the early stages of Alzheimer's disease (AD); however, the underlying mechanisms of these ADinduced sleep disturbances remain unelucidated. To specifically evaluate the involvement of amyloid beta (A beta) oligomers in AD -induced sleep disturbances, we examined circadian and sleep phenotypes using an A beta-GFP transgenic (A beta-GFP Tg) mouse characterized by intracellular accumulation of A beta oligomers. The circadian rhythm and free-running period of wheel running activity were identical between A beta-GFP Tg and littermate wild-type mice. The durations of rapid eye movement (REM) sleep were elongated in A beta-GFP Tg mice; however, the durations of non -REM sleep and wakefulness were unaffected. The A beta-GFP Tg mice exhibited shifts in the electroencephalogram (EEG) power spectra toward higher frequencies in the inactive light phase. These findings suggest that the intracellular accumulation of A beta oligomers might be associated with sleep quality; however, its impact on circadian systems is limited.

引用

页码：186 / 192

页数：7

共 39 条

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