Case Report: In Situ and Systemic Immune Response to Mucosal Leishmaniasis in an HIV-Infected Patient

被引：2

作者：

Amato, Valdir Sabbaga ^{[1
,2
]}

Franco, Lucas Augusto Moyses ^{[1
]}

de Souza, Regina Maia ^{[1
]}

da Silva, Camila Alves Maia ^{[1
]}

Ramundo, Mariana Severo ^{[1
]}

Cortes, Marina Farrel ^{[3
]}

Correa-Castro, Gabriela ^{[4
,5
]}

Santos-Oliveira, Joanna Reis ^{[4
,5
]}

Da-Cruz, Alda M. ^{[4
]}

Pagliari, Carla ^{[6
]}

Galo, Luciane Kanashiro ^{[6
]}

Tuon, Felipe Francisco ^{[7
,8
]}

机构：

[1] Univ Sao Paulo, Fac Med, Lab Parasitol, Inst Med Trop, Sao Paulo, Brazil

[2] Univ Sao Paulo, Fac Med, Dept Doencas & Molestias Infecciosas, Sao Paulo, Brazil

[3] Univ Sao Paulo, Lab Bacteriol & Resistencia Antimicrobiana, Inst Med Trop Sao Paulo, Sao Paulo, Brazil

[4] Fundacao Oswaldo Cruz, Lab Interdisciplinar Pesquisas Med, Inst Oswaldo Cruz, Rio De Janeiro, Brazil

[5] Inst Fed Educ Ciencia & Tecnol IFRJ, Nucleo Ciencias Biomed Aplicadas, Rio De Janeiro, Brazil

[6] Univ Sao Paulo, Fac Med, Dept Patol, Sao Paulo, Brazil

[7] Pontificia Univ Catolica Parana, Lab Doencas Infecciosas & Emergentes, Curitiba, Brazil

[8] Rua Imaculada Conceicao 1155, BR-80215901 Curitiba, Parana, Brazil

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2024年 / 110卷 / 02期

关键词：

CUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS; VIANNIA BRAZILIENSIS; RISK-FACTORS; REACTIVATION; DIAGNOSIS; PCR; ABNORMALITIES; SCANS; CELLS;

D O I：

10.4269/ajtmh.23-0287

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In situ and systemic evaluations of the immune responses of HIV -infected patients to mucosal leishmaniasis have been poorly described. We describe a recently diagnosed HIV -infected patient with mucosal leishmaniasis who was characterized by a CD4 count of 85 cells/mm3 and nasal septum destruction resulting from pruritic and ulcerated nasal mucosa with crust formation and progression over 2 years. In situ and systemic immune evaluations of T cell activation, memory, and exhaustion were conducted using cytofluorometric assays, and sequencing of the Leishmania species was performed. The immune profile of HIV -infected patient with mucosal leishmaniasis shows a mixed Th1/Th2 pattern and an activated and exhausted status.

引用

页码：228 / 233

页数：6

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