Revitalizing the Gut Microbiome in Chronic Kidney Disease: A Comprehensive Exploration of the Therapeutic Potential of Physical Activity

被引：1

作者：

Vandecruys, Marieke ^{[1
]}

De Smet, Stefan ^{[2
]}

De Beir, Jasmine ^{[3
]}

Renier, Marie ^{[4
]}

Leunis, Sofie ^{[5
]}

Van Criekinge, Hanne ^{[5
]}

Glorieux, Griet ^{[6
]}

Raes, Jeroen ^{[7
,8
]}

Wyngaert, Karsten Vanden ^{[6
]}

Nagler, Evi ^{[6
]}

Calders, Patrick ^{[3
]}

Monbaliu, Diethard ^{[5
,9
]}

Cornelissen, Veronique ^{[4
]}

Evenepoel, Pieter ^{[1
,10
]}

Van Craenenbroeck, Amaryllis H. ^{[1
,10
]}

机构：

[1] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Nephrol & Renal Transplantat Res Grp, B-3000 Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Movement Sci, Exercise Physiol Res Grp, B-3000 Leuven, Belgium

[3] Univ Ghent, Dept Rehabil Sci, B-9000 Ghent, Belgium

[4] Katholieke Univ Leuven, Dept Rehabil Sci, Grp Rehabil Internal Disorders, B-3000 Leuven, Belgium

[5] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Abdominal Transplantat, B-3000 Leuven, Belgium

[6] Ghent Univ Hosp, Dept Internal Med & Pediat, Nephrol Sect, B-9000 Ghent, Belgium

[7] Rega Inst Med Res, Dept Microbiol & Immunol, B-3000 Leuven, Belgium

[8] Katholieke Univ Leuven, VIB Ctr Microbiol, B-3000 Leuven, Belgium

[9] Transplantoux Fdn, B-3000 Leuven, Belgium

[10] Univ Hosp Leuven, Dept Nephrol, B-3000 Leuven, Belgium

来源：

TOXINS | 2024年 / 16卷 / 06期

关键词：

chronic kidney disease; gut microbiome; physical activity; exercise; TOLL-LIKE RECEPTOR; INTESTINAL ALKALINE-PHOSPHATASE; IMPAIRS BARRIER FUNCTION; CHRONIC-RENAL-FAILURE; MODERATE EXERCISE; GASTROINTESTINAL TRANSIT; CARDIOVASCULAR-DISEASE; BUTYRATE CONCENTRATION; SYSTEMIC INFLAMMATION; UREMIC TOXINS;

D O I：

10.3390/toxins16060242

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Both physical inactivity and disruptions in the gut microbiome appear to be prevalent in patients with chronic kidney disease (CKD). Engaging in physical activity could present a novel nonpharmacological strategy for enhancing the gut microbiome and mitigating the adverse effects associated with microbial dysbiosis in individuals with CKD. This narrative review explores the underlying mechanisms through which physical activity may favorably modulate microbial health, either through direct impact on the gut or through interorgan crosstalk. Also, the development of microbial dysbiosis and its interplay with physical inactivity in patients with CKD are discussed. Mechanisms and interventions through which physical activity may restore gut homeostasis in individuals with CKD are explored.

引用

页数：28

共 252 条

[1] New Insights on End-Stage Renal Disease and Healthy Individual Gut Bacterial Translocation: Different Carbon Composition of Lipopolysaccharides and Different Impact on Monocyte Inflammatory Response
Adda-Rezig, Hanane
Carron, Clemence
de Barros, Jean-Paul Pais
Choubley, Helene
Charron, Emilie
Rerole, Anne-Laure
Laheurte, Caroline
Louvat, Pascale
Gaiffe, Emilie
Simula-Faivre, Dominique
Deckert, Valerie
Lagrost, Laurent
Saas, Philippe
Ducloux, Didier
Bamoulid, Jamal
[J]. FRONTIERS IN IMMUNOLOGY, 2021, 12
[2] COMPENDIUM OF PHYSICAL ACTIVITIES - CLASSIFICATION OF ENERGY COSTS OF HUMAN PHYSICAL ACTIVITIES
AINSWORTH, BE
HASKELL, WL
LEON, AS
JACOBS, DR
MONTOYE, HJ
SALLIS, JF
PAFFENBARGER, RS
[J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1993, 25 (01) : 71 - 80
[3] Allen JM, 2018, MED SCI SPORT EXER, V50, P747, DOI [10.1249/MSS.0000000000001495, 10.1249/mss.0000000000001495]
[4] Effects of exercise intensity on salivary antimicrobial proteins and markers of stress in active men
Allgrove, Judith E.
Gomes, Elisa
Hough, John
Gleeson, Michael
[J]. JOURNAL OF SPORTS SCIENCES, 2008, 26 (06) : 653 - 661
[5] Intestinal alkaline phosphatase modulation by food components: predictive, preventive, and personalized strategies for novel treatment options in chronic kidney disease
Alvarenga, L.
Cardozo, L. F. M. F.
Lindholm, B.
Stenvinkel, P.
Mafra, D.
[J]. EPMA JOURNAL, 2020, 11 (04) : 565 - 579
[6] The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease
Anders, Hans-Joachim
Andersen, Kirstin
Stecher, Baerbel
[J]. KIDNEY INTERNATIONAL, 2013, 83 (06) : 1010 - 1016
[7] Reduced expression of Toll-like receptor 4 contributes to impaired cytokine response of monocytes in uremic patients
Ando, M.
Shibuya, A.
Tsuchiya, K.
Akiba, T.
Nitta, K.
[J]. KIDNEY INTERNATIONAL, 2006, 70 (02) : 358 - 362
[8] Effects of Different Types of Exercise on Kidney Diseases
Arazi, Hamid
Mohabbat, Majid
Saidie, Payam
Falahati, Akram
Suzuki, Katsuhiko
[J]. SPORTS, 2022, 10 (03)
[9] Blue poo: impact of gut transit time on the gut microbiome using a novel marker
Asnicar, Francesco
Leeming, Emily R.
Dimidi, Eirini
Mazidi, Mohsen
Franks, Paul W.
Al Khatib, Haya
Valdes, Ana M.
Davies, Richard
Bakker, Elco
Francis, Lucy
Chan, Andrew
Gibson, Rachel
Hadjigeorgiou, George
Wolf, Jonathan
Spector, Timothy D.
Segata, Nicola
Berry, Sarah E.
[J]. GUT, 2021, 70 (09) : 1665 - 1674
[10] Endocrine responses of the stress system to different types of exercise
Athanasiou, Nikolaos
Bogdanis, Gregory C.
Mastorakos, George
[J]. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2023, 24 (02) : 251 - 266

← 1 2 3 4 5 6 7 8 9 10 →