Application of 2-Azabicyclo[2.2.1]Hept-5-En-3-One (Vince Lactam) in Synthetic Organic and Medicinal Chemistry

被引：1

作者：

Nonn, Melinda ^{[1
]}

Fustero, Santos ^{[3
]}

Kiss, Lorand ^{[2
]}

机构：

[1] HUN REN Res Ctr Nat Sci, Inst Mat & Environm Chem, MTA TTK Lendulet Artificial Transporter Res Grp, Magyar Tudosok Krt 2, H-1117 Budapest, Hungary

[2] HUN REN Res Ctr Nat Sci, Inst Organ Chem, Stereochem Res Grp, Magyar Tudosok Krt 2, H-1117 Budapest, Hungary

[3] Univ Valencia, Dept Organ Chem, Pharm Fac, Valencia 46100, Burjassot Valen, Spain

来源：

CHEMICAL RECORD | 2024年 / 24卷 / 09期

关键词：

amino acid; functionalization; lactam; selectivity; stereocontrol; STRUCTURE-BASED DESIGN; AMINO-ACIDS; STEREOSELECTIVE-SYNTHESIS; STEREOCONTROLLED ACCESS; PERAMIVIR ANALOGS; DERIVATIVES; FLUORINE; HALOFLUORINATION; METATHESIS; MECHANISM;

D O I：

10.1002/tcr.202400070

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Azabicyclo[2.2.1]hept-5-en-3-one (Vince lactam) is known to be a valuable building block in synthetic organic chemistry and drug research. It is an important precursor to access of some blockbuster antiviral drugs such as Carbovir or Abacavir as well as other carbocyclic neuraminidase inhibitors as antiviral agents. The ring C=C bond of the Vince lactam allows versatile chemical manipulations to create not only functionalized gamma-lactams, but also gamma-amino acid derivatives with a cyclopentane framework. The aim of the current account is to summarize the chemistry of Vince lactam, its synthetic utility and application in organic and medicinal chemistry over the last decade. The current account summarizes the chemistry of Vince lactam, its synthetic utility and application in organic chemistry over the last decade. image

引用

页数：37